Impairment of cognitive function and reduced hippocampal cholinergic activity in a rat model of chronic intermittent hypoxia

被引：1
|
作者：
Zhao, Chunling [1 ]
Chen, Yan [1 ]
Zhang, Chunlai [1 ]
Lue, Linya [2 ]
Xu, Qian [1 ]
机构：
[1] Luzhou Med Coll, Dept Physiol, Luzhou 646000, Sichuan Prov, Peoples R China
[2] Luzhou Med Coll, Affiliated Hosp, Dept Pediat Surg, Luzhou 646000, Sichuan Prov, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 17期
关键词：
hypoxia; brain; memory dysfunction; choline acetyl transferase; nicotinic acetylcholine receptor; chronic intermittent hypoxia; rat; neural regeneration; SPATIAL-LEARNING DEFICITS; ALZHEIMERS-DISEASE; RECEPTORS; ALPHA-7; MEMORY; PLACE;
D O I：
10.3969/j.issn.1673-5374.2011.17.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The present study established a rat model of chronic intermittent hypoxia (CIH) to simulate obstructive sleep apnea syndrome. CIH rats were evaluated for cognitive function using the Morris water maze, and neuronal pathology in the hippocampus was observed using hematoxylin-eosin staining. In addition, hippocampal choline acetyl transferase (ChAT) and nicotinic acetylcholine receptor (nAChR) expression was determined by immunohistochemistry. Our results revealed necrotic hippocampal neurons, decreased ChAT and nAChR expression, as well as cognitive impairment in CIH rats. These results suggest that hippocampal neuronal necrosis and decreased cholinergic activity may be involved in CIH-induced cognitive impairment in rats.
引用
收藏
页码：1301 / 1305
页数：5
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