Synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes containing a chiral tetradentate ligand

被引：4

作者：

Bai, Linkui ^{[1
]}

Gao, Chuanzhu ^{[1
]}

Cai, Linxiang ^{[1
]}

Liu, Qinghua ^{[1
]}

Qian, Yunxu ^{[1
]}

Yang, Bo ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2017年 / 70卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Dinuclear platinum(II) complexes; trans-1R; 2R-Diaminocyclohexane; Cytotoxicity; DNA Insertion group; DOUBLE-HELICAL DNA; ANTICANCER DRUGS; STERIC HINDRANCE; COMPOUND; DIAMINES; CELLS;

D O I：

10.1080/00958972.2017.1398822

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R, 1'R, 2R, 2'R)-N-1, N-1'-(1,2-phenylenebis(methylene))dicyclohexane-1,2-diamine (HL), and mono-carboxylic acid derivatives as ligands have been designed, synthesized, and characterized. In vitro cytotoxicity evaluation of synthesized complexes against human HepG2, A549, HCT-116, and MCF-7 cancer cell lines has been conducted by MTT assays. All compounds showed antitumor activity to HepG-2 and HCT-116 cell lines. Compound L2 exhibited better cytotoxicity than that of carboplatin against HepG-2 and A549 cell lines and also showed comparable activity against HCT-116 cell line. [GRAPHICS]

引用

页码：3759 / 3768

页数：10

共 50 条

[41] Platinum(II) complexes containing aminophosphonate esters: Synthesis, characterization, cytotoxicity and action mechanism
Huang, Ke-Bin
Chen, Zhen-Feng
Liu, Yan-Cheng
Li, Zhu-Quan
Wei, Jian-Hua
Wang, Meng
Xie, Xiao-Li
Liang, Hong
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 64 : 554 - 561
[42] SYNTHESIS OF MIXED LIGAND COMPLEXES OF PLATINUM(II)
WATT, GW
CUDDEBAC.JE
JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1971, 33 (01): : 259 - &
[43] CYTOTOXICITY OF PLATINUM(IV) AND PLATINUM(II) COMPLEXES CONTAINING 1R,2R-CYCLOHEXANEDIAMINE AS A LIGAND
YAMASHITA, T
HIROSE, J
NOJI, M
SAITO, R
TOMIDA, H
KIDANI, Y
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1993, 16 (10) : 1014 - 1018
[44] Bifunctional Platinum(II) Complexes with Bisphosphonates Substituted Diamine Derivatives: Synthesis and In vitro Cytotoxicity
Sun, Yanyan
Zhao, Jian
Ji, Zhongling
CHEMISTRY & BIODIVERSITY, 2017, 14 (12)
[45] Chiral effects on a fluxional ligand: chiral diphosphine platinum(II) complexes with thiacrowns
Grant, GJ
Pool, JA
VanDerveer, DG
DALTON TRANSACTIONS, 2003, (20) : 3981 - 3984
[46] Synthesis, Characterization and Cytotoxicity of Dihalogeno-platinum(II) Complexes with L-Histidine Ligand
Ye, Qing-Song
Xie, Ming-Jin
Liu, Wei-Ping
Chen, Xi-Zhu
Yu, Yao
Chang, Qiao-Wen
Hou, Shu-Qian
CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (04) : 424 - 427
[47] SYNTHESIS AND CHARACTERIZATION OF NEW OSMIUM COMPLEXES CONTAINING A TETRADENTATE, TETRAANIONIC LIGAND
COLLINS, TJ
CHRISTIE, JA
KRAFFT, TE
SANTARSIERO, BD
SPIES, GH
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1983, 185 (MAR): : 239 - INOR
[48] Synthesis, characterization and cytotoxicity of Diam(m)ineplatinum(II) complexes containing β-phenylisosuccinate ligand
Ye, Qing-Song
Lou, Li-Guang
Liu, Zuo-Yan
Liu, Wei-Ping
Hou, Shu-Qian
Chen, Xi-Zhu
Yu, Yao
ARCHIV DER PHARMAZIE, 2007, 340 (11) : 599 - 602
[49] Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(II) and platinum(III) dinuclear complexes
Djinovic, Vesna M.
Galanski, Markus
Arion, Vladimir B.
Keppler, Bernhard K.
DALTON TRANSACTIONS, 2010, 39 (15) : 3633 - 3643
[50] Synthesis, structure and property of manganese(II) complexes with mixed tetradentate imidazole-containing ligand and benzenedicarboxylate
Hua, Qin
Su, Zhi
Zhao, Yue
Okamura, Taka-aki
Xu, Guan-Cheng
Sun, Wei-Yin
Ueyama, Norikazu
INORGANICA CHIMICA ACTA, 2010, 363 (13) : 3550 - 3557

← 1 2 3 4 5 →