Synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes containing a chiral tetradentate ligand

被引：4
|
作者：
Bai, Linkui [1 ]
Gao, Chuanzhu [1 ]
Cai, Linxiang [1 ]
Liu, Qinghua [1 ]
Qian, Yunxu [1 ]
Yang, Bo [1 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2017年 / 70卷 / 22期
基金：
中国国家自然科学基金;
关键词：
Dinuclear platinum(II) complexes; trans-1R; 2R-Diaminocyclohexane; Cytotoxicity; DNA Insertion group; DOUBLE-HELICAL DNA; ANTICANCER DRUGS; STERIC HINDRANCE; COMPOUND; DIAMINES; CELLS;
D O I：
10.1080/00958972.2017.1398822
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of novel dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R, 1'R, 2R, 2'R)-N-1, N-1'-(1,2-phenylenebis(methylene))dicyclohexane-1,2-diamine (HL), and mono-carboxylic acid derivatives as ligands have been designed, synthesized, and characterized. In vitro cytotoxicity evaluation of synthesized complexes against human HepG2, A549, HCT-116, and MCF-7 cancer cell lines has been conducted by MTT assays. All compounds showed antitumor activity to HepG-2 and HCT-116 cell lines. Compound L2 exhibited better cytotoxicity than that of carboplatin against HepG-2 and A549 cell lines and also showed comparable activity against HCT-116 cell line. [GRAPHICS]
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页码：3759 / 3768
页数：10
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