Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence

被引：5

作者：

Kim, DI

Kim, HY ^{[1
]}

Kwon, LS

Park, SD

Jeon, GH

Jung, KY

Min, JK

Nam, WH

Lee, KH

Chung, YS

Tanabe, S

Kozono, T

机构：

[1] C&C Res Labs, Kyunggi Do 445970, South Korea

[2] Chugai Pharmaceut Co Ltd, Fuji Gotemba Res Labs, Shizuoka 4128513, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期

关键词：

cardiovascular activity; antiarrhythmic agent; potassium channel blockers; reverse frequency dependence;

D O I：

10.1016/S0960-894X(98)00689-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：85 / 90

页数：6