Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence

被引：5
|
作者：
Kim, DI
Kim, HY [1 ]
Kwon, LS
Park, SD
Jeon, GH
Jung, KY
Min, JK
Nam, WH
Lee, KH
Chung, YS
Tanabe, S
Kozono, T
机构：
[1] C&C Res Labs, Kyunggi Do 445970, South Korea
[2] Chugai Pharmaceut Co Ltd, Fuji Gotemba Res Labs, Shizuoka 4128513, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期
关键词：
cardiovascular activity; antiarrhythmic agent; potassium channel blockers; reverse frequency dependence;
D O I：
10.1016/S0960-894X(98)00689-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：85 / 90
页数：6
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