Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence

被引：5
|
作者：
Kim, DI
Kim, HY [1 ]
Kwon, LS
Park, SD
Jeon, GH
Jung, KY
Min, JK
Nam, WH
Lee, KH
Chung, YS
Tanabe, S
Kozono, T
机构：
[1] C&C Res Labs, Kyunggi Do 445970, South Korea
[2] Chugai Pharmaceut Co Ltd, Fuji Gotemba Res Labs, Shizuoka 4128513, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期
关键词：
cardiovascular activity; antiarrhythmic agent; potassium channel blockers; reverse frequency dependence;
D O I：
10.1016/S0960-894X(98)00689-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：85 / 90
页数：6
相关论文
共 41 条
  • [1] KCB-328: A novel class III antiarrhythmic agent with little reverse frequency dependence in isolated guinea pig myocardium
    Lee, KH
    Lee, JY
    Kim, HY
    Kwon, LS
    Shin, HS
    Tanabe, S
    Kozono, T
    Park, SD
    Chung, YS
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1998, 31 (04) : 609 - 617
  • [2] Electrophysiological effects of KCB-328, a novel class III antiarrhythmic agent in vitro.
    Lee, K
    Kwon, LS
    Kim, HY
    Tanabe, S
    FASEB JOURNAL, 1996, 10 (03): : 180 - 180
  • [3] Antiarrhythmic effects of a novel class III drug, KCB-328, on canine ventricular arrhythmia models
    Xue, YX
    Tanabe, S
    Nabuchi, Y
    Hashimoto, K
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1998, 32 (02) : 239 - 247
  • [4] Frequency-dependent effects of KCB-328, a novel class III antiarrhythmic agent in isolated guinea pig ventricular muscle.
    Lee, JY
    Lee, K
    Shin, HS
    Kim, HY
    Tanabe, S
    FASEB JOURNAL, 1996, 10 (03): : 179 - 179
  • [5] KCB-328, a novel class III antiarrhythmic agent, blocks delayed rectifier current in atrial tumor cells (AT-1 cell)
    Mull, KP
    Debnam, Q
    Kabir, SM
    Bhattacharyya, ML
    BIOPHYSICAL JOURNAL, 1998, 74 (02) : A159 - A159
  • [6] Differential recovery of action potential duration and HERG currents from the effects of two methanesulfonamide class III antiarrhythmic agents, KCB-328 and dofetilide
    Lee, K
    Park, JB
    Jeon, BH
    Kim, KJ
    Ryu, PD
    Kwon, LS
    Kim, HY
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2003, 42 (05) : 648 - 655
  • [7] Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores
    Koufaki, Maria
    Kiziridi, Christina
    Papazafiri, Panagiota
    Vassilopoulos, Athanasios
    Varro, Andras
    Nagy, Zsolt
    Farkas, Attila
    Makriyannis, Alexandros
    BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (19) : 6666 - 6678
  • [8] Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents
    Hong, Suckchang
    Shin, Yoonho
    Jung, Myunggi
    Ha, Min Woo
    Park, Yohan
    Lee, Yeon-Ju
    Shin, Jongheon
    Oh, Ki Bong
    Lee, Sang Kook
    Park, Hyeung-geun
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 96 : 218 - 230
  • [9] SYNTHESIS, CARDIAC ELECTROPHYSIOLOGY, AND BETA-BLOCKING ACTIVITY OF NOVEL ARYLPIPERAZINES WITH POTENTIAL AS CLASS II/III ANTIARRHYTHMIC AGENTS
    PHILLIPS, GB
    MORGAN, TK
    LUMMA, WC
    GOMEZ, RP
    LIND, JM
    LIS, R
    ARGENTIERI, T
    SULLIVAN, ME
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (04) : 743 - 750
  • [10] New p-methylsulfonamido phenylethylamine analogues as class III antiarrhythmic agents:: Design, synthesis, biological assay, and 3D-QSAR analysis
    Liu, H
    Ji, M
    Luo, XM
    Shen, JH
    Huang, XQ
    Hua, WY
    Jiang, HL
    Chen, KX
    JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (14) : 2953 - 2969
12345