Backbone and side-chain chemical shift assignments of MarH, a critical intermediary epimerase for biosynthesis of Maremycins in Streptomyces

被引：1
|
作者：
Liu, Bin [1 ,2 ]
Fang, Shiqi [1 ,2 ]
Ma, Xiaofang [1 ,2 ]
Bai, Zhiqiang [1 ,2 ]
Hu, Kaifeng [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
BIOMOLECULAR NMR ASSIGNMENTS | 2018年 / 12卷 / 02期
基金：
中国国家自然科学基金;
关键词：
MarH; Epimerase; NMR; Chemical shift assignments; BIOMOLECULAR NMR; SUPERFAMILY;
D O I：
10.1007/s12104-018-9835-2
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
MarH is an essential epimerase that catalyzes the isomerization of 3R--methyl-indolepyruvate (-MeInPy) to 3S--MeInPy, which is the important precursor for biosynthesis of Maremycins. Biophysical study of the structure of MarH would be informative for better understanding of its catalytic mechanism and feasible application of the enzyme in isomerization reaction. Here, we report the backbone and side-chain NMR chemical shift assignments of MarH, which lays a foundation for further structural and mechanical study of the enzyme.
引用
收藏
页码：335 / 338
页数：4
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