Human leukocyte antigen-A, -B, and-DRB1 allele and haplotype frequencies in the Mozambican population: A blood donor-based population study

被引：14
|
作者：
Assane, Antonio A. A. [1 ,2 ]
Fabricio-Silva, Gustavo M. [1 ]
Cardoso-Oliveira, Juliana [1 ]
Mabunda, Nedio E. J. [3 ]
Sousa, Amina M. [3 ]
Jani, Ilesh V. [3 ]
Ferreira, Orlando C., Jr. [1 ]
Porto, Luis C. M. S. [1 ]
机构：
[1] Univ Estado Rio De Janeiro, Roberto Alcantara Gomes Inst Biol, Dept Histol & Embryol, Histocompatibil & Cryopreservat Lab, Rio De Janeiro, Brazil
[2] Minist Hlth, Maputo Cent Hosp, Clin Lab, Maputo, Mozambique
[3] Minist Hlth, Natl Inst Hlth, Dept Immunol, Immunol Lab, Maputo, Mozambique
来源：
HUMAN IMMUNOLOGY | 2010年 / 71卷 / 10期
关键词：
Mozambique Basin; Alleles; Blood donors; Maputo; Haplotypes; HLA-CLASS-I; AFRICAN POPULATIONS; COMPLEX DISEASE; DIVERSITY; ASSOCIATION; SYSTEM; POLYMORPHISM; IMMUNOLOGY; GENETICS; SUPPORTS;
D O I：
10.1016/j.humimm.2010.06.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human leukocyte antigen (HLA) has been used for several decades as genetic markers for analyzing diversity of gene pool origin, platelet transfusion, tissue transplantation, disease susceptibility or resistance, and forensic and anthropological studies. In the present study, the allele and haplotype frequencies of HLA-A, -B, and -DRB1 were studied in 250 unrelated Mozambican individuals (black African from south of Mozambique Basin) by using a low-medium resolution polymerase chain reaction-Luminex typing method. A total of 18 A. 25 B, and 13 DRB1 alleles were identified. The most frequent HLA-A, -B, and -DRB1 alleles were HLA-A*30 (23.9%), HLA-B*15 (15.6%), and HLA-DRB1*13 (19.8%), respectively. The most frequent two-locus haplotypes were HLA-A*30-B*42 (7.4%) and HLA-B*42-DRB1*03 (5.4%), and three-locus haplotypes were HLA-A*30-B*42-DRB1*03 (4.9%), and HLA-A*02-B*58-DRB1*11 (4.1%). Allele distribution and haplotype analysis demonstrated that Mozambican population shares HLA patterns with sub-Saharan populations. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：1027 / 1032
页数：6
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