HLA-A, -B and-DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

被引:18
|
作者
Galgani, Andrea [1 ]
Mancino, Giorgio [2 ]
Martinez-Labarga, Cristina [3 ]
Cicconi, Rosella [1 ]
Mattei, Maurizio [1 ]
Amicosante, Massimo [4 ]
Bonanno, Cesira T. [5 ]
Di Sano, Caterina [6 ]
Gimil, Giuma Salem [7 ]
Salerno, Alfredo [5 ]
Colizzi, Vittorio [3 ]
Montesano, Carla [3 ]
机构
[1] Univ Roma Tor Vergata, Ctr Serv Interdipartimentale, Stn Tecnol Anim, I-00133 Rome, Italy
[2] S Pietro Hosp, Res Ctr, Rome, Italy
[3] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
[4] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy
[5] Univ Palermo, Dept Pathol & Biomed Methodol, I-90133 Palermo, Italy
[6] CNR, Inst Biomed & Mol Immunol, Palermo, Italy
[7] Tripoli Med Ctr, Dept Hematol, Tripoli, Libya
关键词
CLASS-I; HAPLOTYPE FREQUENCIES; BALEARIC-ISLANDS; POLYMORPHISM; ORIGIN; RELATEDNESS; TUNISIANS; MOROCCAN; SPAIN; DNA;
D O I
10.1016/j.humimm.2012.10.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The frequencies of HLA-A, HLA-B and HLA-DRB1 alleles in 118 unrelated Libyans from Benghazi (Cyrenaica) were analysed using high resolution typing and compared with other populations. Their relatedness has been tested by correspondence analyses and principal component analysis. The most frequent HLA-A alleles were A*02:01:01:01 (15.7%), A*01:01:01:01 (11.4%) and A*03:01:01:01 (9.3%). For the HLA-B locus, the commonest allele was HLA-B*50:01:01 (14.4%) followed by B*51:01:01 (9.8%) and B*08:01:01 (6.4%). For the HLA-DRB1 locus, the commonest was HLA-DRB1*07:01:01:01 (16.9%) followed by DRB1*03:01:01:01 (13.6%) and DRB1*13:02:01 (9.3%). The most frequent two-locus haplotypes were HLA-A*02:01:01:01-B*07:02:01 (3.0%) and HLA-B*50:01:01-DRB1*07:01:01:01 (9.6%), and three-locus haplotypes were HLA-A*02:01:01:01-B*50:01:01-DRB1*07:01:01:01 (4.2%) and HLA-A*11:01:01-B*52:01:01:01-DRB1*15:02:01 (2.5%). This study is the first on the HLA status of a Libyan population. The results, when compared to similar HLA data obtained previously from African and Mediterranean populations, indicate genetic influences from several ethnic groups. Moreover, the differences in the HLA allele frequencies between the Libyan population and others reveals that significant admixture has occurred between the original Berber inhabitants and neighbouring and more distant populations, even though a strong genetic Berber substratum remains. These data will be of value to future anthropological and disease association studies involving the Libyan population. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:52 / 59
页数:8
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