affinity based screening;
cellular imaging;
high-throughput screening;
D O I:
10.1517/17460441.1.3.195
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The last decade showed a further upsurge in screening technology advance and innovation. Notably, the establishment of ultra high-throughput screening facilities led to an explosion of screening capacities. However, in the last 2 years, a turning point in screening philosophy can be observed worldwide. Increasingly more companies are reducing the size of screening campaigns, while increasing the emphasis on data quality and relevance. This article tries to investigate how screening technologies will develop in the ever-changing landscape of drug discovery.
机构:Central University of Punjab,Laboratory for Drug Design and Synthesis, Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences
Pankaj Kumar Singh
Arvind Negi
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机构:Central University of Punjab,Laboratory for Drug Design and Synthesis, Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences
Arvind Negi
Pawan Kumar Gupta
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机构:Central University of Punjab,Laboratory for Drug Design and Synthesis, Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences
Pawan Kumar Gupta
Monika Chauhan
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机构:Central University of Punjab,Laboratory for Drug Design and Synthesis, Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences
Monika Chauhan
Raj Kumar
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机构:Central University of Punjab,Laboratory for Drug Design and Synthesis, Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences
机构:
Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
CSGID, Bethesda, MD USA
MCSG, Mesa, AZ USA
NYSGRC, New York, NY USAUniv Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
Zheng, Heping
Hou, Jing
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h-index: 0
机构:
Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
CSGID, Bethesda, MD USA
Enzyme Struct Initiat EFI, Urbana, IL USA
NYSGRC, New York, NY USAUniv Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
Hou, Jing
Zimmerman, Matthew D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
CSGID, Bethesda, MD USA
Enzyme Struct Initiat EFI, Urbana, IL USA
MCSG, Mesa, AZ USA
NYSGRC, New York, NY USAUniv Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
Zimmerman, Matthew D.
Wlodawer, Alexander
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h-index: 0
机构:
NCI, Ctr Canc Res, Frederick, MD 21702 USAUniv Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
Wlodawer, Alexander
Minor, Wladek
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
CSGID, Bethesda, MD USA
Enzyme Struct Initiat EFI, Urbana, IL USA
MCSG, Mesa, AZ USA
NYSGRC, New York, NY USAUniv Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA