Mesenchymal stromal cell 'licensing': a multistep process

被引：290
|
作者：
Krampera, M. [1 ]
机构：
[1] Univ Verona, Stem Cell Res Lab, Policlin GB Rossi, Dept Med,Sect Hematol, I-37134 Verona, Italy
来源：
LEUKEMIA | 2011年 / 25卷 / 09期
关键词：
mesenchymal stromal cells; licensing; immune regulation; HUMAN BONE-MARROW; VERSUS-HOST-DISEASE; ANTIGEN-PRESENTING CELL; SUPPRESS T-LYMPHOCYTE; TOLL-LIKE RECEPTORS; ADULT STEM-CELLS; INTERFERON-GAMMA; DENDRITIC CELLS; ADIPOSE-TISSUE; NITRIC-OXIDE;
D O I：
10.1038/leu.2011.108
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects. Leukemia (2011) 25, 1408-1414; doi: 10.1038/leu.2011.108; published online 27 May 2011
引用
收藏
页码：1408 / 1414
页数：7
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