Mesenchymal stromal cell ‘licensing’: a multistep process

被引：0
|
作者：
M Krampera
机构：
[1] Stem Cell Research Laboratory,Department of Medicine
[2] Section of Hematology,undefined
[3] University of Verona,undefined
来源：
Leukemia | 2011年 / 25卷
关键词：
mesenchymal stromal cells; licensing; immune regulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects.
引用
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页码：1408 / 1414
页数：6
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