Mesenchymal stromal cell 'licensing': a multistep process

被引：290
|
作者：
Krampera, M. [1 ]
机构：
[1] Univ Verona, Stem Cell Res Lab, Policlin GB Rossi, Dept Med,Sect Hematol, I-37134 Verona, Italy
来源：
LEUKEMIA | 2011年 / 25卷 / 09期
关键词：
mesenchymal stromal cells; licensing; immune regulation; HUMAN BONE-MARROW; VERSUS-HOST-DISEASE; ANTIGEN-PRESENTING CELL; SUPPRESS T-LYMPHOCYTE; TOLL-LIKE RECEPTORS; ADULT STEM-CELLS; INTERFERON-GAMMA; DENDRITIC CELLS; ADIPOSE-TISSUE; NITRIC-OXIDE;
D O I：
10.1038/leu.2011.108
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects. Leukemia (2011) 25, 1408-1414; doi: 10.1038/leu.2011.108; published online 27 May 2011
引用
收藏
页码：1408 / 1414
页数：7
相关论文
共 50 条
  • [21] In situ licensing of mesenchymal stem cell immunomodulatory function via BMP-2 induced developmental process
    Zhu, Fuwei
    Ji, Luli
    Dai, Kai
    Deng, Shunshu
    Wang, Jing
    Liu, Changsheng
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 121 (48)
  • [22] SINGLE CELL PROTEIN PROCESS TARGETED FOR LICENSING
    KRIEGER, J
    CHEMICAL & ENGINEERING NEWS, 1983, 61 (31) : 21 - 21
  • [23] Mesenchymal Stromal Cell Therapy in Lung Transplantation
    Nykanen, Antti I.
    Liu, Mingyao
    Keshavjee, Shaf
    BIOENGINEERING-BASEL, 2023, 10 (06):
  • [24] Mesenchymal stromal cells in hematopoietic cell transplantation
    Burnham, Andre J.
    Daley-Bauer, Lisa P.
    Horwitz, Edwin M.
    BLOOD ADVANCES, 2020, 4 (22) : 5877 - 5887
  • [25] Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases
    Staff, Nathan P.
    Jones, David T.
    Singer, Wolfgang
    MAYO CLINIC PROCEEDINGS, 2019, 94 (05) : 892 - 905
  • [26] SERS Imaging of Mesenchymal Stromal Cell Differentiation
    Milewska, Adrianna
    Sigurjonsson, Olafur E.
    Leosson, Kristjan
    ACS APPLIED BIO MATERIALS, 2021, 4 (06): : 4999 - 5007
  • [27] Mesenchymal stromal cell senescence in haematological malignancies
    Natalya Plakhova
    Vasilios Panagopoulos
    Kate Vandyke
    Andrew C. W. Zannettino
    Krzysztof M. Mrozik
    Cancer and Metastasis Reviews, 2023, 42 : 277 - 296
  • [28] Implications of multipotent mesenchymal stromal cell aging
    Stochaj, Ursula
    Kodiha, Mohamed
    Shum-Tim, Dominique
    Colmegna, Ines
    REGENERATIVE MEDICINE, 2013, 8 (02) : 211 - 222
  • [29] Mesenchymal Stromal Cell-Based Therapy
    Moench, Dina
    Reinders, Marlies E. J.
    Hoogduijn, Martin J.
    Dahlke, Marc-Hendrik
    CELLS, 2023, 12 (04)
  • [30] COVID in the wild and mesenchymal stromal cell therapy
    Cebra, Christopher K.
    Tornquist, Susan J.
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 2024, 85 (02)
12345