Pt(II) complexes of the type trans-[PtCl2(DMSO) (hydrazide)] and cis-[PtCl2(hydrazide)2]: Solvolysis and cytotoxic activity

被引：3
|
作者：
de Oliveira, Leticia P. [1 ]
de Souza, Ivina P. [2 ]
Paixao, Drielly A. [1 ]
Sousa, Luana M. [1 ]
Lima, Mauricio F. [1 ]
Pereira, Caroline de S. [3 ]
Silva, Heveline [3 ]
Pereira-Maia, Elene C. [2 ]
Guerra, Wendell [1 ]
机构：
[1] Univ Fed Uberlandia, Inst Quim, Av Joao Naves de Avila 2121,Campus Santa Monica, BR-38400902 Uberlandia, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Quim, Campus Pampulha, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Juiz de Fora, Dept Quim, BR-36036900 Juiz De Fora, MG, Brazil
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2019年 / 1192卷
关键词：
Pt(II) complexes; Solvolysis; Hydrazide; Cytotoxic activity; DINUCLEAR PLATINUM COMPLEXES; ACID HYDRAZIDES; COPPER(II) COMPLEXES; PD(II) COMPLEXES; REACTIVITY; PALLADIUM(II); GLYCINE; DRUGS;
D O I：
10.1016/j.molstruc.2019.04.134
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present work describes the synthesis, solvolysis and cytotoxic activity of Pt (II) complexes of the type trans-[PtCl2 (DMSO) (L)] and cis-[PtCl2(L)(2)], where L = benzhydrazide (BH), 4-nitrobenzhydrazide (4NH) and 4-(trifluoromethyl)benzhydrazide (4 TF). The structures of these complexes were proposed using spectroscopic methods. All complexes undergo fast solvolysis generating four identical species in DMSO, being that the species cis- and trans-[PtCl2 (DMSO) (L)] are the most important. As to the stability in DMF, Pt (II) complexes of the type cis-[PtCl2(L)(2)] are very stable, while Pt (II) complexes of the type trans-[PtCl2 (DMSO) (L)] react at a slower rate than those verified in DMSO. The cytotoxic activity of the compounds was evaluated in a chronic myelogenous leukemia cell line. A relationship between solvolysis and cytotoxic activity was verified. Moreover, our results showed that some Pt (II) complexes were more cytotoxic than the free ligands, carboplatin and cisplatin. (C) 2019 Elsevier B.V. All rights reserved.
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页码：76 / 81
页数：6
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