Reduction of cis,trans,cis-[PtCl2(OCOCH3)2(NH3)2] by aqueous extracts of cancer cells

被引：90
|
作者：
Nemirovski, Alina [1 ]
Kasherman, Yonit [1 ]
Tzaraf, Yael [1 ]
Gibson, Dan [1 ]
机构：
[1] Hebrew Univ Jerusalem, Dept Med Chem & Nat Prod, Sch Pharm, David R Bloom Ctr Pharm, IL-91120 Jerusalem, Israel
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 23期
关键词：
D O I：
10.1021/jm070740j
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pt(IV) complexes must be reduced to kill cancer cells. While reduction rates correlate with reduction potentials, we wanted to check if the rates of reduction depend on the cell line used. The reduction of cis,trans,cis-[PtCl2(OCOCH3)(2)(NH3)(2)] by extracts of three cell lines was measured, and the rates follow the order A2780cisR > A2780 > HT29. The reduction is not carried out by the low molecular weight (MW) antioxidants but primarily by cellular components with MW > 3000.
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页码：5554 / 5556
页数：3
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