Synthesis of 1-amino-3-[2-(1,7-dicarba-closo-dodecaboran(12)-1-yl)ethyl]cyclobutane-carboxylic acid: A potential BNCT agent

被引：36

作者：

Srivastava, RR

Singhaus, RR

Kabalka, GW

机构：

[1] UNIV TENNESSEE,DEPT CHEM,KNOXVILLE,TN 37996

[2] UNIV TENNESSEE,DEPT RADIOL,KNOXVILLE,TN 37996

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 13期

关键词：

D O I：

10.1021/jo970148+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of an unnatural amino add, 1-amino-3-[2-(1,17-dicarba-closo-dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic acid, was achieved. This new potential BNCT agent was prepared via the mono alkylation of m-carborane with 4-bromobutene to produce 4-m-carboranyl-1-butene, which was then subjected to a 2 + 2 cycloaddition using dichloroketene. The resultant boronated cyclobutanone was reductively dechlorinated prior to the formation of the corresponding hydantoin, which was hydrolized to the title compound in excellent yield.

引用

页码：4476 / 4478

页数：3

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