A Novel One-pot Three-step Synthesis of 2-(1-Benzofuran-2-yl)quinoline-3-carboxylic Acid Derivatives

被引：18
|
作者：
Gao, Wentao [1 ]
Zhang, Chaohua [1 ]
Li, Yang [1 ]
机构：
[1] Bohai Univ, Inst Superfine Chem, Jinzhou 121000, Peoples R China
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2010年 / 21卷 / 05期
关键词：
one-pot; three-step; benzofuran; quinoline; 2-SUBSTITUTED QUINOLINES; EFFICIENT SYNTHESIS; HETEROCYCLES; INHIBITORS; 1,8-NAPHTHYRIDINES; ANNULATIONS; ANALOGS; KETONES; PROFILE; SERIES;
D O I：
10.1590/S0103-50532010000500007
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile and efficient one-pot three-step procedure for the preparation of 2-(1-benzofuran-2-yl) quinoline-3-carboxylic acid derivatives is described, featuring three different synthetic transformations, namely Williamson ether synthesis, hydrolysis of an ester group at the quinoline ring C-3 position, and intramolecular electrophilic cyclization reaction between the aldehyde group of salicylaldehyde and the methylene at the quinoline ring C-2 position.
引用
收藏
页码：806 / 812
页数：7
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