Crystal structure of RhoA-GDP and its functional implications

被引：157

作者：

Wei, YY ^{[1
]}

Zhang, Y ^{[1
]}

Derewenda, U ^{[1
]}

Liu, XP ^{[1
]}

Minor, W ^{[1
]}

Nakamoto, RK ^{[1
]}

Somlyo, AV ^{[1
]}

Somlyo, AP ^{[1
]}

Derewenda, ZS ^{[1
]}

机构：

[1] UNIV VIRGINIA, HLTH SCI CTR, CTR STRUCT BIOL, DEPT MOL PHYSIOL & BIOL PHYS, CHARLOTTESVILLE, VA 22906 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 09期

关键词：

D O I：

10.1038/nsb0997-699

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 Angstrom resolution crystal structure of the human RhoA-GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.

引用

页码：699 / 703

页数：5

共 50 条

[41] RABBIT MUSCLE CREATINE KINASE - CRYSTAL STRUCTURE AND ITS IMPLICATIONS.
Rao, J. K. Mohana
Wlodawer, Alexander
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1999, 55 : 270 - 270
[42] Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP
Douglas M. Freymann
Robert J. Keenan
Robert M. Stroud
Peter Walter
Nature Structural Biology, 1999, 6 : 793 - 801
[43] Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP
Freymann, DM
Keenan, RJ
Stroud, RM
Walter, P
NATURE STRUCTURAL BIOLOGY, 1999, 6 (08) : 793 - 801
[44] The crystal structure of bovine heart cytochrome c oxidase, functional implications.
Yoshikawa, S
Shinzawa-Itoh, K
Tsukihara, T
FASEB JOURNAL, 1997, 11 (09): : A858 - A858
[45] Functional implications of tRNA Mimicry. Crystal Structure of Ribosome Recycling Factor
Selmer, M.
Al-Karadaghi, S.
Hirokawa, G.
Kaji, A.
Liljas, A.
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2000, 56 : S81 - S81
[46] Crystal structure analyses of uncomplexed ecotin in two crystal forms: Implications for its function and stability
Shin, DH
Song, HK
Seong, IS
Lee, CS
Chung, CH
Suh, SW
PROTEIN SCIENCE, 1996, 5 (11) : 2236 - 2247
[47] Crystal structure of cbbF from Zymomonas mobilis and its functional implication
Hwang, Hyo-Jeong
Park, Suk-Youl
Kim, Jeong-Sun
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 445 (01) : 78 - 83
[48] Dimeric structure of the cell shape protein MreC and its functional implications
van den Ent, Fusinita
Leaver, Mark
Bendezu, Felipe
Errington, Jeff
de Boer, Piet
Lowe, Jan
MOLECULAR MICROBIOLOGY, 2006, 62 (06) : 1631 - 1642
[49] THE EFFECT OF CALDESMON ON THE STRUCTURE OF ACTIN-FILAMENTS AND ITS FUNCTIONAL IMPLICATIONS
DABROWSKA, R
NOWAK, E
BOROVIKOV, YS
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 1990, 11 (01) : 58 - 58
[50] Heme Pocket Structure and Its Functional Implications in an Ancestral Globin Protein
Iritani, Yu
Ishikawa, Haruto
Mizuno, Misao
Mizutani, Yasuhisa
BIOCHEMISTRY, 2023, 62 (18) : 2727 - 2737

← 1 2 3 4 5 →