Crystal structure of RhoA-GDP and its functional implications

被引：157

作者：

Wei, YY ^{[1
]}

Zhang, Y ^{[1
]}

Derewenda, U ^{[1
]}

Liu, XP ^{[1
]}

Minor, W ^{[1
]}

Nakamoto, RK ^{[1
]}

Somlyo, AV ^{[1
]}

Somlyo, AP ^{[1
]}

Derewenda, ZS ^{[1
]}

机构：

[1] UNIV VIRGINIA, HLTH SCI CTR, CTR STRUCT BIOL, DEPT MOL PHYSIOL & BIOL PHYS, CHARLOTTESVILLE, VA 22906 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 09期

关键词：

D O I：

10.1038/nsb0997-699

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 Angstrom resolution crystal structure of the human RhoA-GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.

引用

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页码：699 / 703

页数：5

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