Complex trait genetics the role of mechanistic - "Intermediate phenotypes" and candidate genetic loci

被引：2
|
作者：
Rao, Fangwen [1 ,2 ,3 ]
O'Connor, Daniel T. [1 ,2 ,3 ]
机构：
[1] Univ Calif San Diego, Ctr Human Genet & Gen, Dept Pharmacol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Ctr Human Genet & Gen, Dept Pharmacol, La Jolla, CA 92093 USA
[3] Vet Adm San Diego Healthcare Syst, San Diego, CA USA
来源：
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2008年 / 52卷 / 02期
关键词：
D O I：
10.1016/j.jacc.2008.02.080
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：166 / 168
页数：3
相关论文
共 50 条
  • [11] Systems genetics approach reveals candidate genes for parasite resistance from quantitative trait loci studies in agricultural species
    Sayre, B. L.
    Harris, G. C.
    [J]. ANIMAL GENETICS, 2012, 43 (02) : 190 - 198
  • [12] Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes
    Blanco-Gomez, Adrian
    Castillo-Lluva, Sonia
    del Mar Saez-Freire, Maria
    Hontecillas-Prieto, Lourdes
    Mao, Jian Hua
    Castellanos-Martin, Andres
    Perez-Losada, Jesus
    [J]. BIOESSAYS, 2016, 38 (07) : 664 - 673
  • [13] Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
    Farhad Hormozdiari
    Steven Gazal
    Bryce van de Geijn
    Hilary K. Finucane
    Chelsea J.-T. Ju
    Po-Ru Loh
    Armin Schoech
    Yakir Reshef
    Xuanyao Liu
    Luke O’Connor
    Alexander Gusev
    Eleazar Eskin
    Alkes L. Price
    [J]. Nature Genetics, 2018, 50 : 1041 - 1047
  • [14] Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
    Hormozdiari, Farhad
    Gazal, Steven
    van de Geijn, Bryce
    Finucane, Hilary K.
    Ju, Chelsea J. -T.
    Loh, Po-Ru
    Schoech, Armin
    Reshef, Yakir
    Liu, Xuanyao
    O'Connor, Luke
    Gusev, Alexander
    Eskin, Eleazar
    Price, Alkes L.
    [J]. NATURE GENETICS, 2018, 50 (07) : 1041 - +
  • [15] Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations
    Nica, Alexandra C.
    Montgomery, Stephen B.
    Dimas, Antigone S.
    Stranger, Barbara E.
    Beazley, Claude
    Barroso, Ines
    Dermitzakis, Emmanouil T.
    [J]. PLOS GENETICS, 2010, 6 (04)
  • [16] The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits
    Long, AD
    Langley, CH
    [J]. GENOME RESEARCH, 1999, 9 (08) : 720 - 731
  • [17] Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes
    Ways, Justin A.
    Smith, Brian M.
    Barbato, John C.
    Ramdath, Ramona S.
    Pettee, Krista M.
    DeRaedt, Sarah J.
    Allison, David C.
    Koch, Lauren G.
    Lee, Soon Jin
    Cicila, George T.
    [J]. PHYSIOLOGICAL GENOMICS, 2007, 29 (01) : 91 - 97
  • [18] Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster
    Long, AD
    Mullaney, SL
    Mackay, TFC
    Langley, CH
    [J]. GENETICS, 1996, 144 (04) : 1497 - 1510
  • [19] Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci - A None-Experimental Solution
    Wang, Lishi
    Jiao, Yan
    Wang, Yongjun
    Zhang, Mengchen
    Gu, Weikuan
    [J]. PLOS ONE, 2016, 11 (05):
  • [20] Genotype matrix mapping: Searching for quantitative trait loci interactions in genetic variation in complex traits
    Isobe, Sachiko
    Nakaya, Akihiro
    Tabata, Satoshi
    [J]. DNA RESEARCH, 2007, 14 (05) : 217 - 225
12345