Enteric-coated mycophenolate sodium immunosuppression in renal transplant patients: efficacy and dosing

被引：19
|
作者：
Cooper, Matthew [1 ]
Salvadori, Maurizio [2 ]
Budde, Klemens [3 ]
Oppenheimer, Frederic [4 ]
Sollinger, Hans [5 ]
Zeier, Martin [6 ]
机构：
[1] Univ Maryland, Sch Med, Div Transplantat, Baltimore, MD 21201 USA
[2] Univ Careggi, Unita Operat Nefrol Dialisi & Trapianti, Azienda Osped, Florence, Italy
[3] Charite, Dept Nephrol, D-13353 Berlin, Germany
[4] Hosp Clin Barcelona, Serv Nefrol, E-08036 Barcelona, Spain
[5] Univ Wisconsin, Dept Surg, Sch Med & Publ Hlth, Madison, WI USA
[6] Heidelberg Univ, Dept Med, Div Nephrol, D-6900 Heidelberg, Germany
来源：
TRANSPLANTATION REVIEWS | 2012年 / 26卷 / 04期
关键词：
Efficacy; EC-MPS; Immunosuppression; MMF; Mycophenolic acid; Kidney transplant; GI tolerability; INOSINE MONOPHOSPHATE DEHYDROGENASE; QUALITY-OF-LIFE; ACUTE REJECTION; GASTROINTESTINAL COMPLICATIONS; MOFETIL MMF; EC-MPS; KIDNEY-TRANSPLANTATION; CONTROLLED-TRIAL; DOSE REDUCTION; OPEN-LABEL;
D O I：
10.1016/j.trre.2012.02.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mycophenolate mofetil (MMF), a mycophenolic acid (MPA) formulation, has improved both short- and long-term outcomes following renal transplantation, but is often associated with gastrointestinal (GI) complications that can lead to dose reduction or discontinuation, potentially jeopardizing patient outcomes. Enteric-coated mycophenolate sodium (EC-MPS) delivers equivalent MPA exposure to MMF and offers the potential to reduce GI burden (while maintaining patient safety). Here we review the efficacy of EC-MPS compared with MMF in renal transplant patients in terms of biopsy-proven acute rejection and graft loss, and examine the use of EC-MPS in newer regimens such as intensified dosing and calcineurin inhibitor minimization. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：233 / 240
页数：8
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