MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma

被引：70
|
作者：
Kan, Takatsugu [1 ]
Meltzer, Stephen J. [2 ,3 ,4 ]
机构：
[1] Kyoto Univ Hosp, Dept Surg, Kyoto 6068507, Japan
[2] Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol, Baltimore, MD 21287 USA
[3] Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA
[4] Johns Hopkins Univ, Dept Oncol, Div Gastroenterol, Sch Med, Baltimore, MD 21287 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 06期
关键词：
EXPRESSION PROFILES; DOWN-REGULATION; CELL-GROWTH; PREVALENCE; PROGRESSION; METAPLASIA; DYSPLASIA; CANCER; INVOLVEMENT; SUPPRESSION;
D O I：
10.1016/j.coph.2009.08.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.
引用
收藏
页码：727 / 732
页数：6
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