MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma

被引：39

作者：

Smith, Cameron M. ^{[1
]}

Watson, David I. ^{[1
]}

Michael, Michael Z. ^{[2
]}

Hussey, Damian J. ^{[1
]}

机构：

[1] Flinders Univ S Australia, Dept Surg, Flinders Med Ctr, Bedford Pk, SA 5042, Australia

[2] Flinders Univ S Australia, Dept Gastroenterol & Hepatol, Bedford Pk, SA 5042, Australia

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 05期

关键词：

Barrett's esophagus; MicroRNA; Esophageal adenocarcinoma; Transdifferentiation; Tumour suppressor; HUMAN BREAST-CANCER; EXPRESSION PROFILES; SUPPRESSOR GENE; STEM-CELLS; MIRNAS; ACID; METASTASIS; METAPLASIA; CARCINOMA; MIR-21;

D O I：

10.3748/wjg.v16.i5.531

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esophageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is becoming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. (C) 2010 Baishideng. All rights reserved.

引用

页码：531 / 537

页数：7

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