MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma

被引：70
|
作者：
Kan, Takatsugu [1 ]
Meltzer, Stephen J. [2 ,3 ,4 ]
机构：
[1] Kyoto Univ Hosp, Dept Surg, Kyoto 6068507, Japan
[2] Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol, Baltimore, MD 21287 USA
[3] Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA
[4] Johns Hopkins Univ, Dept Oncol, Div Gastroenterol, Sch Med, Baltimore, MD 21287 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 06期
关键词：
EXPRESSION PROFILES; DOWN-REGULATION; CELL-GROWTH; PREVALENCE; PROGRESSION; METAPLASIA; DYSPLASIA; CANCER; INVOLVEMENT; SUPPRESSION;
D O I：
10.1016/j.coph.2009.08.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.
引用
收藏
页码：727 / 732
页数：6
相关论文
共 50 条
  • [31] Familial aggregation of Barrett's esophagus and esophageal adenocarcinoma
    Lee, TJ
    Brock, WE
    Goddard, K
    Faulx, AL
    Willis, JE
    Cooper, GS
    Kinnard, M
    Sivak, MV
    Chak, A
    [J]. GASTROINTESTINAL ENDOSCOPY, 2001, 53 (05) : AB143 - AB143
  • [32] Improving Care in Barrett's Esophagus and Esophageal Adenocarcinoma
    Shaheen, Nicholas J.
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2014, 59 (09) : 2015 - 2015
  • [33] Dendritic Cells in Barrett’s Esophagus and Esophageal Adenocarcinoma
    Yuri V. Bobryshev
    Dinh Tran
    Murray C. Killingsworth
    Michael Buckland
    Reginald V. N. Lord
    [J]. Journal of Gastrointestinal Surgery, 2009, 13 : 44 - 53
  • [34] Experimental models for Barrett's esophagus and esophageal adenocarcinoma
    Garman, Katherine S.
    Orlando, Roy C.
    Chen, Xiaoxin
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 302 (11): : G1231 - G1243
  • [35] Barrett?s Esophagus and Esophageal Adenocarcinoma: A Histopathological Perspective
    Zyla, Roman E.
    Kalimuthu, Sangeetha N.
    [J]. THORACIC SURGERY CLINICS, 2022, 32 (04) : 413 - 424
  • [36] Esophageal microbiome signature in patients with Barrett's esophagus and esophageal adenocarcinoma
    Lopetuso, Loris Riccardo
    Severgnini, Marco
    Pecere, Silvia
    Ponziani, Francesca Romana
    Boskoski, Ivo
    Larghi, Alberto
    Quaranta, Gianluca
    Masucci, Luca
    Ianiro, Gianluca
    Camboni, Tania
    Gasbarrini, Antonio
    Costamagna, Guido
    Consolandi, Clarissa
    Cammarota, Giovanni
    [J]. PLOS ONE, 2020, 15 (05):
  • [37] CHARACTERIZATION OF ESOPHAGEAL MICROBIOTA IN PATIENTS WITH BARRETT'S ESOPHAGUS AND ESOPHAGEAL ADENOCARCINOMA
    Lopetuso, L. R.
    Severgnini, M.
    Ianiro, G.
    Pecere, S.
    Boskoski, I.
    Quaranta, G.
    Camboni, T.
    Scaldaferri, F.
    Riccioni, M.
    Masucci, L.
    Consolandi, C.
    Gasbarrini, A.
    Costamagna, G.
    Cammarota, G.
    [J]. DIGESTIVE AND LIVER DISEASE, 2019, 51 : E107 - E107
  • [38] Barrett Esophagus and Intramucosal Esophageal Adenocarcinoma
    Rajendra, Shanmugarajah
    Sharma, Prateek
    [J]. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2017, 31 (03) : 409 - +
  • [39] Esophageal adenocarcinoma arising in Barrett esophagus
    Zhang, Hui Ying
    Spechler, Stuart Jon
    Souza, Rhonda F.
    [J]. CANCER LETTERS, 2009, 275 (02) : 170 - 177
  • [40] The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma
    Contino, Gianmarco
    Vaughan, Thomas L.
    Whiteman, David
    Fitzgerald, Rebecca C.
    [J]. GASTROENTEROLOGY, 2017, 153 (03) : 657 - +
12345