Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-Ala-Cys-NHMe with disulfide linkage

被引：4
|
作者：
Yoshimoto, J
Nishinaga, A
Oka, M
Hayashi, T
机构：
[1] UNIV OSAKA PREFECTURE,ADV SCI & TECHNOL RES INST,SAKAI,OSAKA 593,JAPAN
[2] NAGOYA UNIV,GRAD SCH HUMAN INFORMAT,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN
[3] OSAKA INST TECHNOL,DEPT APPL CHEM,ASAHI KU,OSAKA 535,JAPAN
来源：
POLYMER BULLETIN | 1997年 / 38卷 / 02期
关键词：
D O I：
10.1007/s002890050042
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Theoretical conformational analysis was carried out for the acyclic and cyclic tetrapeptides Ac-Cys-Pro-Ala-Cys-NHMe using ECEPP and optimization procedure for investigating the conformational preference of peptides having disulfide linkage. Calculated results indicate that cyclic Ac-Cys-Pro-Ala-Cys-NHMe forms compactly fold conformations with type III-III double bend at the Pro-Ala-Ala portion, and also show fairly good agreement with experimental results of the NMR spectroscopy for the tetrapeptides having Cys-Pro-Ala-Cys sequence.
引用
收藏
页码：227 / 234
页数：8
相关论文
共 33 条
  • [21] Conformational preferences of Ac-Pro-azaXaa-NHMe (Xaa = Asn, Asp, Ala) and the effect of intramolecular hydrogen bonds on their stability in gas phase and solution
    El Khabchi, Mouna
    Lahlou, Hiba
    El Adnani, Zineb
    Mcharfi, Mohammed
    Benzakour, Mohammed
    Fitri, Asmae
    Benjelloun, Adil Touimi
    [J]. JOURNAL OF MOLECULAR MODELING, 2021, 27 (12)
  • [22] Conformational preferences of Ac-Pro-azaXaa-NHMe (Xaa = Asn, Asp, Ala) and the effect of intramolecular hydrogen bonds on their stability in gas phase and solution
    Mouna El Khabchi
    Hiba Lahlou
    Zineb El Adnani
    Mohammed Mcharfi
    Mohammed Benzakour
    Asmae Fitri
    Adil Touimi Benjelloun
    [J]. Journal of Molecular Modeling, 2021, 27
  • [23] Conformational investigation of α,β-dehydropeptides.: XVI.: β-turn tendency in Ac-Pro-ΔXaa-NHMe:: crystallographic and theoretical studies
    Broda, Malgorzata A.
    Ciszak, Ewa M.
    Koziol, Anna E.
    Pietrzynski, Grzegorz
    Rzeszotarska, Barbara
    [J]. JOURNAL OF PEPTIDE SCIENCE, 2006, 12 (08) : 538 - 549
  • [24] CHAIN-FOLDING INITIATION STRUCTURES IN RIBONUCLEASE-A - CONFORMATIONAL-ANALYSIS OF TRANS-AC-ASN-PRO-TYR-NHME AND TRANS-AC-TYR-PRO-ASN-NHME IN WATER AND IN THE SOLID-STATE
    MONTELIONE, GT
    ARNOLD, E
    MEINWALD, YC
    STIMSON, ER
    DENTON, JB
    HUANG, SG
    CLARDY, J
    SCHERAGA, HA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (25) : 7946 - 7958
  • [25] MULTIPLE CONFORMATIONS AND CONFORMATIONAL CHANGE IN THE ACETONITRILE OF CATION-BINDING CYCLIC TETRAPEPTIDE, CYCLO[GLY-L-CYS(BZL(OME))-SAR-L-PRO]
    SHIMIZU, T
    TANAKA, Y
    TSUDA, K
    [J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1982, 55 (12) : 3817 - 3823
  • [26] CONFORMATIONAL-ANALYSIS OF SMALL DISULFIDE LOOPS - SPECTROSCOPIC AND THEORETICAL-STUDIES ON A SYNTHETIC CYCLIC TETRAPEPTIDE CONTAINING CYSTINE
    VENKATACHALAPATHI, YV
    PRASAD, BVV
    BALARAM, P
    [J]. BIOCHEMISTRY, 1982, 21 (22) : 5502 - 5509
  • [27] Theoretical conformational analysis of periodic polypeptides composed of repetitive Ala-Pro-Xaa-Yaa sequence
    Oka, M
    Hayashi, T
    [J]. PEPTIDE CHEMISTRY 1995, 1996, : 469 - 472
  • [28] CONFORMATIONAL ENERGY ANALYSIS OF THE PENTAPEPTIDE AC-ARG-ASN-CYS-TYR-ASN-NMA FROM ALPHA-1-PUROTHIONIN
    FELLER, DC
    ZIMMERMAN, SS
    VERNON, LP
    [J]. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1989, 34 (06): : 487 - 491
  • [29] THEORETICAL CONFORMATIONAL-ANALYSIS OF BRADYKININ-POTENTIATING PEPTIDES .6. CONFORMATIONAL MOBILITY OF THE BACKBONE AND SIDE-CHAINS OF THE LOW-ENERGY STRUCTURES OF LESS-THAN GLU-LYS-TRP-ALA-PRO AND LESS-THAN GLU-LYS-TRP-PRO-PRO
    SEVASTIJANOVA, NN
    POPOV, EM
    [J]. BIOORGANICHESKAYA KHIMIYA, 1981, 7 (02): : 189 - 198
  • [30] THEORETICAL CONFORMATIONAL-ANALYSIS OF BRADYKININ-POTENTIATING PENTAPEPTIDE LESS-THAN L-CLU-L-LYS-L-TRP-L-ALA-L-PRO .3.
    SEVASTIJANOVA, NN
    POPOV, EM
    [J]. BIOORGANICHESKAYA KHIMIYA, 1978, 4 (08): : 997 - 1016
1234