Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-Ala-Cys-NHMe with disulfide linkage

被引：4
|
作者：
Yoshimoto, J
Nishinaga, A
Oka, M
Hayashi, T
机构：
[1] UNIV OSAKA PREFECTURE,ADV SCI & TECHNOL RES INST,SAKAI,OSAKA 593,JAPAN
[2] NAGOYA UNIV,GRAD SCH HUMAN INFORMAT,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN
[3] OSAKA INST TECHNOL,DEPT APPL CHEM,ASAHI KU,OSAKA 535,JAPAN
来源：
POLYMER BULLETIN | 1997年 / 38卷 / 02期
关键词：
D O I：
10.1007/s002890050042
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Theoretical conformational analysis was carried out for the acyclic and cyclic tetrapeptides Ac-Cys-Pro-Ala-Cys-NHMe using ECEPP and optimization procedure for investigating the conformational preference of peptides having disulfide linkage. Calculated results indicate that cyclic Ac-Cys-Pro-Ala-Cys-NHMe forms compactly fold conformations with type III-III double bend at the Pro-Ala-Ala portion, and also show fairly good agreement with experimental results of the NMR spectroscopy for the tetrapeptides having Cys-Pro-Ala-Cys sequence.
引用
收藏
页码：227 / 234
页数：8
相关论文
共 33 条
  • [11] Preferred conformations of cyclic Ac-Cys-Pro-Xaa-Cys-NHMe peptides: a model for chain reversal and active site of disulfide oxidoreductase
    Park, HS
    Kim, C
    Kang, YK
    [J]. BIOPHYSICAL CHEMISTRY, 2003, 105 (01) : 89 - 104
  • [12] THEORETICAL CONFORMATIONAL-ANALYSIS ON ELASTIN MODEL TETRAPEPTIDE AC-VAL-PRO-GLY-GLY-NHME
    OKA, M
    BABA, Y
    KAGEMOTO, A
    NAKAJIMA, A
    [J]. POLYMER JOURNAL, 1989, 21 (07) : 585 - 591
  • [13] THEORETICAL-ANALYSIS OF AC-L-ALA-L-PRO-L-ALA-NHME CONFORMATIONS WITH INTRAMOLECULAR HYDROGEN-BONDS
    GROMOV, EP
    PLETNEV, VZ
    [J]. KHIMIYA PRIRODNYKH SOEDINENII, 1976, (02): : 233 - 238
  • [14] Characterization of (Boc-Cys/Sec-NHMe)2 and (Boc-Cys/Sec-OMe)2: Evidence of local conformational difference between disulfide and diselenide
    Dolle, Ashwini
    Reddy, K. Kasi Amarnath
    Gunaga, Shubha Shridhar
    Krishnamurthy, Kiran
    Senapati, Dillip Kumar
    Rana, Abhijit
    Sindogi, Kishorkumar
    Biswal, Himansu S.
    Raghothama, Srinivasarao
    Gowd, Konkallu Hanumae
    [J]. JOURNAL OF PEPTIDE SCIENCE, 2020, 26 (4-5)
  • [15] CHAIN REVERSALS IN MODEL PEPTIDES - STUDIES OF CYSTINE-CONTAINING CYCLIC-PEPTIDES .3. CONFORMATIONAL FREE-ENERGIES OF CYCLIZATION OF TETRAPEPTIDES OF SEQUENCE AC-CYS-PRO-X-CYS-NHME
    FALCOMER, CM
    MEINWALD, YC
    CHOUDHARY, I
    TALLURI, S
    MILBURN, PJ
    CLARDY, J
    SCHERAGA, HA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (11) : 4036 - 4042
  • [16] CYCLIC PEPTIDE DISULFIDES - SOLUTION AND SOLID-STATE CONFORMATION OF BOC-CYS-PRO-AIB-CYS-S-S-BRIDGE-NHME,A DISULFIDE-BRIDGED PEPTIDE HELIX
    RAVI, A
    PRASAD, BVV
    BALARAM, P
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (01) : 105 - 109
  • [17] CHAIN REVERSALS IN MODEL PEPTIDES - STUDIES OF CYSTINE-CONTAINING CYCLIC-PEPTIDES .1. CONFORMATIONAL FREE-ENERGIES OF CYCLIZATION OF HEXAPEPTIDES OF SEQUENCE AC-CYS-X-PRO-GLY-Y-CYS-NHME
    MILBURN, PJ
    KONISHI, Y
    MEINWALD, YC
    SCHERAGA, HA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (15) : 4486 - 4496
  • [18] THEORETICAL ANALYSIS OF CONFORMATIONS OF AC-GLY-L-ALA-GLY-NHME WITH INTRAMOLECULAR HYDROGEN-BONDS
    PLETNEV, VZ
    KADYMOVA, FA
    POPOV, EM
    [J]. BIOPOLYMERS, 1974, 13 (06) : 1085 - 1092
  • [19] Conformational analysis of small peptides of the type Ac-X-NHMe, where X = Gly, Ala, Aib and Cage
    Bisetty, K
    Catalan, JG
    Kruger, H
    Perez, JJ
    [J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 2005, 731 (1-3): : 127 - 137
  • [20] Identification and Conformer Analysis of a Novel Redox-Active Motif, Pro-Ala-Ser-Cys-Cys-Ser, in Drosophila Thioredoxin Reductase by Semiempirical Molecular Orbital Calculation
    Kuwahara, Mitsuhiko
    Tamura, Takashi
    Kawamura, Kentaro
    Inagaki, Kenji
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2011, 75 (03) : 516 - 521
1234