Synthesis of Chiral Sulfamide-Amine Alcohol Ligands for Enantioselective Alkylation of Aldehydes

被引：10
|
作者：
Mao, Jincheng [1 ]
机构：
[1] Suzhou Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 20期
基金：
中国国家自然科学基金;
关键词：
Amine alcohols; asymmetric addition; diethylzinc; enantioselectivities; ASYMMETRIC ADDITIONS; ORGANOZINC REAGENTS; DIETHYLZINC; BENZALDEHYDE; ALKYNYLATION; DIALKYLZINC; ORIGIN;
D O I：
10.1080/00397910902806265
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of chiral sulfamide-amine alcohols (SAA) (1-6) has been easily synthesized from commercially available chiral amino alcohols. In the absence of Ti(OiPr)4, ligand 4 catalyzed the asymmetric addition of diethylzinc to aromatic aldehydes with moderate to good yields and enantioselectivities.
引用
收藏
页码：3710 / 3721
页数：12
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