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Role of skeletal muscle autophagy in high-fat-diet-induced obesity and exercise
被引:14
|作者:
Herrenbruck, Adrienne R.
[1
]
Bollinger, Lance M.
[1
]
机构:
[1] Univ Kentucky, Dept Kinesiol & Hlth Promot, Lexington, KY USA
关键词:
INSULIN-RESISTANCE;
UBIQUITIN;
MITOCHONDRIA;
DEGRADATION;
MITOPHAGY;
ULK1;
DYSFUNCTION;
BIOGENESIS;
ADAPTATION;
STARVATION;
D O I:
10.1093/nutrit/nuz044
中图分类号:
R15 [营养卫生、食品卫生];
TS201 [基础科学];
学科分类号:
100403 ;
摘要:
Autophagy is a complex degradation pathway responsible for clearing damaged and dysfunctional organelles. High-fat-diet-induced obesity has been shown to alter autophagy throughout the body in a tissue-specific manner. The impact of obesity on skeletal muscle autophagy has yet to be elucidated. This review examines the impact of high-fat-diet-induced obesity and exercise on skeletal muscle autophagy. Better understanding this major quality control mechanism may help develop novel therapies to combat high-fat-diet-induced obesity comorbidities.
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页码:56 / 64
页数:9
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