Role of skeletal muscle autophagy in high-fat-diet-induced obesity and exercise

被引：14

作者：

Herrenbruck, Adrienne R. ^{[1
]}

Bollinger, Lance M. ^{[1
]}

机构：

[1] Univ Kentucky, Dept Kinesiol & Hlth Promot, Lexington, KY USA

来源：

NUTRITION REVIEWS | 2020年 / 78卷 / 01期

关键词：

INSULIN-RESISTANCE; UBIQUITIN; MITOCHONDRIA; DEGRADATION; MITOPHAGY; ULK1; DYSFUNCTION; BIOGENESIS; ADAPTATION; STARVATION;

D O I：

10.1093/nutrit/nuz044

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Autophagy is a complex degradation pathway responsible for clearing damaged and dysfunctional organelles. High-fat-diet-induced obesity has been shown to alter autophagy throughout the body in a tissue-specific manner. The impact of obesity on skeletal muscle autophagy has yet to be elucidated. This review examines the impact of high-fat-diet-induced obesity and exercise on skeletal muscle autophagy. Better understanding this major quality control mechanism may help develop novel therapies to combat high-fat-diet-induced obesity comorbidities.

引用

页码：56 / 64

页数：9

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