The role of extracellular matrix on liver stem cell fate: A dynamic relationship in health and disease

被引：16

作者：

Sanchez-Romero, Natalia ^{[1
]}

Sainz-Arnal, Pilar ^{[1
,2
]}

Pla-Palacin, Iris ^{[1
]}

Royo Dachary, Pablo ^{[1
]}

Almeida, Helen ^{[1
]}

Pastor, Cristina ^{[2
]}

Rubio Soto, Daniela ^{[1
,5
,6
]}

Chico Rodriguez, Milagros ^{[3
]}

Olmedo Arbizu, Emma ^{[3
]}

Bengochea Martinez, Lourdes ^{[3
]}

Serrano-Aullo, Trinidad ^{[1
]}

Baptista, Pedro M. ^{[1
,4
,5
,6
]}

机构：

[1] Hlth Res Inst Aragon IIS Aragon, Zaragoza, Spain

[2] Aragons Hlth Sci Res Inst IACS, Zaragoza, Spain

[3] Univ Hosp Lozano Blesa, Pathol Dept, Zaragoza, Spain

[4] CIBERehd, Barcelona, Spain

[5] Jimenez Diaz Fdn IIS FJD, Hlth Res Inst, Madrid, Spain

[6] Univ Carlos III Madrid, Biomed & Aerosp Engn Dept, Madrid, Spain

来源：

DIFFERENTIATION | 2019年 / 106卷

关键词：

Liver development; ECM; Stem cell; Progenitor cell; Stem cell niche; Growth factors; Mechanobiology; MULTIPOTENT STEM/PROGENITOR CELLS; LONG-TERM CULTURE; GROWTH-FACTOR; BILIARY TREE; ADHESION MOLECULES; PROGENITOR CELLS; ADULT LIVER; NICHE; REGENERATION; MECHANISMS;

D O I：

10.1016/j.diff.2019.03.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matrix (ECM) components involved in the regulation of stem cell fate (self-renewal, survival, and differentiation into more mature phenotypes like hepatocytes and cholangiocytes). In this review, we describe and summarize all the major components that play essential roles in the liver stem cell niche, in particular, growth factor signaling and the biomechanical properties of the ECM.

引用

页码：49 / 56

页数：8

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