The role of extracellular matrix on liver stem cell fate: A dynamic relationship in health and disease

被引：13

作者：

Sanchez-Romero, Natalia ^{[1
]}

Sainz-Arnal, Pilar ^{[1
,2
]}

Pla-Palacin, Iris ^{[1
]}

Royo Dachary, Pablo ^{[1
]}

Almeida, Helen ^{[1
]}

Pastor, Cristina ^{[2
]}

Rubio Soto, Daniela ^{[1
,5
,6
]}

Chico Rodriguez, Milagros ^{[3
]}

Olmedo Arbizu, Emma ^{[3
]}

Bengochea Martinez, Lourdes ^{[3
]}

Serrano-Aullo, Trinidad ^{[1
]}

Baptista, Pedro M. ^{[1
,4
,5
,6
]}

机构：

[1] Hlth Res Inst Aragon IIS Aragon, Zaragoza, Spain

[2] Aragons Hlth Sci Res Inst IACS, Zaragoza, Spain

[3] Univ Hosp Lozano Blesa, Pathol Dept, Zaragoza, Spain

[4] CIBERehd, Barcelona, Spain

[5] Jimenez Diaz Fdn IIS FJD, Hlth Res Inst, Madrid, Spain

[6] Univ Carlos III Madrid, Biomed & Aerosp Engn Dept, Madrid, Spain

来源：

DIFFERENTIATION | 2019年 / 106卷

关键词：

Liver development; ECM; Stem cell; Progenitor cell; Stem cell niche; Growth factors; Mechanobiology; MULTIPOTENT STEM/PROGENITOR CELLS; LONG-TERM CULTURE; GROWTH-FACTOR; BILIARY TREE; ADHESION MOLECULES; PROGENITOR CELLS; ADULT LIVER; NICHE; REGENERATION; MECHANISMS;

D O I：

10.1016/j.diff.2019.03.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matrix (ECM) components involved in the regulation of stem cell fate (self-renewal, survival, and differentiation into more mature phenotypes like hepatocytes and cholangiocytes). In this review, we describe and summarize all the major components that play essential roles in the liver stem cell niche, in particular, growth factor signaling and the biomechanical properties of the ECM.

引用

页码：49 / 56

页数：8

共 50 条

[21] Interplay of Extracellular Matrix Stiffness and Tethering in Regulating Stem Cell Fate.
Wen, J. H.
Vincent, L. G.
Fuhrmann, A.
Choi, Y.
Hribar, K. C.
Taylor-Weiner, H.
Chen, S.
Engler, A. J.
MOLECULAR BIOLOGY OF THE CELL, 2014, 25
[22] Extracellular Matrix Proteins are Necessary for Mouse Embryonic Stem Cell Differentiation and May Guide Stem Cell Fate
Taylor-Weiner, Hermes
Engler, Adam J.
BIOPHYSICAL JOURNAL, 2012, 102 (03) : 719A - 719A
[23] Extracellular matrix: The dynamic structural and functional network in health and disease
Karamanos, Nikos
Ricard-Blum, Sylvie
Kletsas, Dimitris
IUBMB LIFE, 2022, 74 (10) : 926 - 926
[24] Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment
McQuitty, Claire E.
Williams, Roger
Chokshi, Shilpa
Urbani, Luca
FRONTIERS IN IMMUNOLOGY, 2020, 11
[25] Extracellular Matrix and Liver Disease
Arriazu, Elena
Ruiz de Galarreta, Marina
Cubero, Francisco Javier
Varela-Rey, Marta
Pilar Perez de Obanos, Maria
Leung, Tung Ming
Lopategi, Aritz
Benedicto, Aitor
Abraham-Enachescu, Ioana
Nieto, Natalia
ANTIOXIDANTS & REDOX SIGNALING, 2014, 21 (07) : 1078 - 1097
[26] 3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate
Nicolas, Julien
Magli, Sofia
Rabbachin, Linda
Sampaolesi, Susanna
Nicotra, Francesco
Russo, Laura
BIOMACROMOLECULES, 2020, 21 (06) : 1968 - 1994
[27] Arsenic Directs Stem Cell Fate by Imparting Notch Signaling Into the Extracellular Matrix Niche
Anguiano, Teresa
Sahu, Amrita
Qian, Baoli
Tang, Wan-Yee
Ambrosio, Fabrisia
Barchowsky, Aaron
TOXICOLOGICAL SCIENCES, 2020, 177 (02) : 494 - 505
[28] Embryonic Extracellular Matrix and Cell Fate Determination
Kren, Stefan M.
Chapman, Christopher S.
Loza, Andrew
Garry, Daniel J.
Garry, Mary G.
CIRCULATION RESEARCH, 2015, 117
[29] Matrix control of stem cell fate
Even-Ram, Sharona
Artym, Vira
Yamada, Kenneth M.
CELL, 2006, 126 (04) : 645 - 647
[30] The Extracellular Matrix in Health and Disease
Eble, Johannes A.
CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (12) : 1275 - 1276

← 1 2 3 4 5 →