Effect of oral sulfenamide TS administration on prenatal development in rats

被引：0
|
作者：
Sitarek, K
Berlinska, B
Baranski, B
机构：
[1] Dept. Carcinogenesis, T., Nofer Inst. of Occupational Medicine, Łódź
[2] Dept. Carcinogenesis, T., Nofer Inst. of Occupational Medicine, 90-950 Łódź
来源：
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS | 1996年 / 16卷 / 01期
关键词：
sulfenamide TS; prenatal development; rats; internal hydrocephalus; organogenesis;
D O I：
10.1002/(SICI)1520-6866(1996)16:1<1::AID-TCM1>3.0.CO;2-M
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sulfenamide TS (N-cyclohexyl-2-benzothiazolesulfenamide), accelerator of rubber vulcanization, was administered to female rats by gavage at doses of 50, 150, and 450 mg/kg (1%, 3%, and 8% of LD(50)) during organogenesis. The maternal toxicity of Sulfenamide TS was found at the highest dose of 450 mg/kg. Oral administration of this compound to female rats during organogenesis induced fetotoxic effects at doses of 50 mg/kg and higher. The dose-dependent increase in the frequency of fetuses/litters with internal hydrocephalus was observed. (C) 1996 Wiley-Liss, Inc.
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页码：1 / 6
页数：6
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