Effect of oral sulfenamide TS administration on prenatal development in rats

被引：0
|
作者：
Sitarek, K
Berlinska, B
Baranski, B
机构：
[1] Dept. Carcinogenesis, T., Nofer Inst. of Occupational Medicine, Łódź
[2] Dept. Carcinogenesis, T., Nofer Inst. of Occupational Medicine, 90-950 Łódź
来源：
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS | 1996年 / 16卷 / 01期
关键词：
sulfenamide TS; prenatal development; rats; internal hydrocephalus; organogenesis;
D O I：
10.1002/(SICI)1520-6866(1996)16:1<1::AID-TCM1>3.0.CO;2-M
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sulfenamide TS (N-cyclohexyl-2-benzothiazolesulfenamide), accelerator of rubber vulcanization, was administered to female rats by gavage at doses of 50, 150, and 450 mg/kg (1%, 3%, and 8% of LD(50)) during organogenesis. The maternal toxicity of Sulfenamide TS was found at the highest dose of 450 mg/kg. Oral administration of this compound to female rats during organogenesis induced fetotoxic effects at doses of 50 mg/kg and higher. The dose-dependent increase in the frequency of fetuses/litters with internal hydrocephalus was observed. (C) 1996 Wiley-Liss, Inc.
引用
收藏
页码：1 / 6
页数：6
相关论文
共 50 条
  • [11] EFFECT OF PRENATAL ADMINISTRATION OF ANDROGEN ON REPRODUCTIVE FUNCTION IN FEMALE RATS
    OGAWA, S
    NOZAWA, A
    ENDOCRINOLOGIA JAPONICA, 1969, 16 (06): : 599 - &
  • [12] The Effect on Bodyweight of Rats after Inhalation Administration Compared to Oral Administration
    Moore, S.
    Ettridge, N.
    Damiano, J.
    INTERNATIONAL JOURNAL OF TOXICOLOGY, 2022, 41 (01) : 52 - 52
  • [13] INFLUENCE OF PRENATAL D-AMPHETAMINE ADMINISTRATION ON DEVELOPMENT AND BEHAVIOR OF RATS
    HITZEMANN, BA
    HITZEMANN, RJ
    BRASE, DA
    LOH, HH
    LIFE SCIENCES, 1976, 18 (06) : 605 - 612
  • [14] Effect of Systemic Administration of Amitriptyline on Oral Microbes in Rats
    Ninomiya, Kazunori
    Paudel, Durga
    Uehara, Osamu
    Morikawa, Tetsuro
    Islam, Syed Taufiqul
    Khurelchuluun, Ariuntsetseg
    Ariwansa, Dedy
    Yoshida, Koki
    Matsuoka, Hirofumi
    Hajime, Hara
    Kayoko, Fukui
    Nakamura, Kenjirou
    Abiko, Yoshihiro
    IN VIVO, 2022, 36 (05): : 2134 - 2142
  • [15] EFFECTS OF PRENATAL MALNUTRITION ON DEVELOPMENT OF ORAL-TISSUE IN NEONATAL RATS
    WINKLER, MM
    NAKAMOTO, T
    ANNALS OF NUTRITION AND METABOLISM, 1982, 26 (04) : 248 - 253
  • [16] Effect of group housing and oral corticosterone administration on weight gain and locomotor development in neonatal rats
    Young, LA
    PavlovskaTeglia, G
    Stodulski, G
    Hau, J
    ANIMAL WELFARE, 1996, 5 (02) : 167 - 176
  • [17] PRENATAL ADMINISTRATION OF MORPHINE TO MICE AND RATS - ANALGESIC EFFECT OF MORPHINE IN OFFSPRING
    OCALLAGHAN, JP
    FEDERATION PROCEEDINGS, 1975, 34 (03) : 714 - 714
  • [18] The effect of prenatal/postnatal nicotine administration on oxidant/antioxidant status in rats
    Myzrak, S.
    Alper, G. Ercan
    Caglayan, O.
    Yylmaz, C.
    FEBS JOURNAL, 2010, 277 : 117 - 117
  • [19] Effect of prenatal administration of fluvoxamine on morphophysiological parameters and behavior of white rats
    Gruzdev, G.
    Voronina, Y. A.
    Manchenko, D. M.
    Glazova, N. Y.
    Levitskaya, N. G.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2017, 27 : S681 - S681
  • [20] EFFECT OF CHLORAMPHENICOL ON PRENATAL DEVELOPMENT OF RATS, MICE, AND RABBITS
    FRITZ, H
    HESS, R
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1971, 19 (04) : 667 - &
12345