Effect of oral sulfenamide TS administration on prenatal development in rats

被引：0

作者：

Sitarek, K

Berlinska, B

Baranski, B

机构：

[1] Dept. Carcinogenesis, T., Nofer Inst. of Occupational Medicine, Łódź

[2] Dept. Carcinogenesis, T., Nofer Inst. of Occupational Medicine, 90-950 Łódź

来源：

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS | 1996年 / 16卷 / 01期

关键词：

sulfenamide TS; prenatal development; rats; internal hydrocephalus; organogenesis;

D O I：

10.1002/(SICI)1520-6866(1996)16:1<1::AID-TCM1>3.0.CO;2-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sulfenamide TS (N-cyclohexyl-2-benzothiazolesulfenamide), accelerator of rubber vulcanization, was administered to female rats by gavage at doses of 50, 150, and 450 mg/kg (1%, 3%, and 8% of LD(50)) during organogenesis. The maternal toxicity of Sulfenamide TS was found at the highest dose of 450 mg/kg. Oral administration of this compound to female rats during organogenesis induced fetotoxic effects at doses of 50 mg/kg and higher. The dose-dependent increase in the frequency of fetuses/litters with internal hydrocephalus was observed. (C) 1996 Wiley-Liss, Inc.

引用

页码：1 / 6

页数：6

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