Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp KY002

被引：31
|
作者：
Abdelfattah, Mohamed S. [1 ]
Kharel, Madan Kumar [1 ]
Hitron, John Andrew [1 ]
Baig, Irfan [1 ]
Rohr, Juergen [1 ]
机构：
[1] Univ Kentucky, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40536 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1021/np800281f
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomzyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.
引用
收藏
页码：1569 / 1573
页数：5
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