Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp KY002

被引：31

作者：

Abdelfattah, Mohamed S. ^{[1
]}

Kharel, Madan Kumar ^{[1
]}

Hitron, John Andrew ^{[1
]}

Baig, Irfan ^{[1
]}

Rohr, Juergen ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40536 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1021/np800281f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomzyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

引用

页码：1569 / 1573

页数：5

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