FPGA-Based Lock-In Amplifier for Measuring the Electrical Properties of Individual Cells

被引:0
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作者
Divakar, Dipin [1 ]
Mahesh, Karthik [1 ]
Varma, Manoj M. [1 ]
Sen, Prosenjit [1 ]
机构
[1] Indian Inst Sci, Ctr Nano Sci & Engn CeNSE, Bangalore, Karnataka, India
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中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
We report the design and validation of a low-cost and portable FPGA-based lock-in amplifier (LIA) for measuring the dielectric properties of cells through electrical impedance spectroscopy (EIS). The proposed design uses the phase sensitive measurement principle which detects the signal at a particular reference frequency and rejects the rest. By closely integrating the LIA with a custom-built instrumentation amplifier and a microfluidic device, we demonstrate the excellent ability of the system to suppress noise and detect impedance changes due to flowing red blood cells (RBCs).
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页码:413 / 416
页数:4
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