The translocator protein (TSPO): A novel target for cancer chemotherapy

被引：73

作者：

Austin, Christopher J. D. ^{[1
]}

Kahlert, Jan ^{[1
]}

Kassiou, Michael ^{[1
]}

Rendina, Louis M. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2013年 / 45卷 / 07期

关键词：

Translocator protein; TSPO; Cancer; Apoptosis; Cell homoeostasis; PERIPHERAL BENZODIAZEPINE-RECEPTOR; 18 KDA TSPO; MITOCHONDRIAL PERMEABILITY TRANSITION; DEPENDENT ANION CHANNELS; BINDING-SITES; COLONIC ADENOCARCINOMA; CHOLESTEROL TRANSPORT; DISEASE STATES; LIGANDS; TUMORS;

D O I：

10.1016/j.biocel.2013.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The translocator protein (TSPO) is an 18 kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the mitochondrial permeability transition pore (MFTP). Omnipresent in almost all tissues, TSPO up-regulation has been connected to neuronal damage and inflammation, making the protein an important bio-imaging marker for disease progression. More recently, TSPO has attracted attention as a possible molecular target for tumour imaging and chemotherapy. In this review we summarize TSPO's molecular characteristics and highlight research progress in recent years in the field of TSPO-targeted cancer diagnostics and treatments. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

引用

下载

页码：1212 / 1216

页数：5

共 50 条

[41] The Physiology and Pharmacology of the Mitochondrial 18 kDa Translocator Protein (TSPO): An Emerging Molecular Target for Diagnosis and Therapy
Campanella, Michelangelo
CURRENT MOLECULAR MEDICINE, 2012, 12 (04) : 355 - 355
[42] Structural Prediction of the Dimeric Form of the Mammalian Translocator Membrane Protein TSPO: A Key Target for Brain Diagnostics
Zeng, Juan
Guareschi, Riccardo
Damre, Mangesh
Cao, Ruyin
Kless, Achim
Neumaier, Bernd
Bauer, Andreas
Giorgetti, Alejandro
Carloni, Paolo
Rossetti, Giulia
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (09)
[43] Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?
Li, Fei
Liu, Jian
Liu, Nan
Kuhn, Leslie A.
Garavito, R. Michael
Ferguson-Millert, Shelagh
BIOCHEMISTRY, 2016, 55 (20) : 2821 - 2831
[44] In vivo imaging translocator protein (TSPO) in autism spectrum disorder
Dominic Simpson
Avideh Gharehgazlou
Tania Da Silva
Charlotte Labrie-Cleary
Alan A. Wilson
Jeffrey H. Meyer
Romina Mizrahi
Pablo M. Rusjan
Neuropsychopharmacology, 2022, 47 : 1421 - 1427
[45] TRANSLATIONAL EVALUATION OF TRANSLOCATOR PROTEIN (TSPO) AS A MARKER OF NEUROINFLAMMATION IN SCHIZOPHRENIA
Notter, Tina
Coughlin, Jennifer
Gschwind, Tilo
Weber-Stadlbauer, Ulrike
Wang, Yuchuan
Kassiou, Michael
Vernon, Anthony
Benke, Dietmar
Pomper, Martin
Sawa, Akira
Meyer, Urs
SCHIZOPHRENIA BULLETIN, 2017, 43 : S64 - S64
[46] Mitochondrial Translocator Protein (TSPO) Is a Regulator of Fatty Acid Metabolism
Tu, Lan N.
Zhao, Amy H.
Hussein, Mahmoud
Selvaraj, Vimal
FASEB JOURNAL, 2016, 30
[47] In vivo imaging translocator protein (TSPO) in autism spectrum disorder
Simpson, Dominic
Gharehgazlou, Avideh
Da Silva, Tania
Labrie-Cleary, Charlotte
Wilson, Alan A.
Meyer, Jeffrey H.
Mizrahi, Romina
Rusjan, Pablo M.
NEUROPSYCHOPHARMACOLOGY, 2022, 47 (07) : 1421 - 1427
[48] Metal complexes targeting the Translocator Protein 18 kDa (TSPO)
Denora, Nunzio
Iacobazzi, Rosa Maria
Natile, Giovanni
Margiotta, Nicola
COORDINATION CHEMISTRY REVIEWS, 2017, 341 : 1 - 18
[49] 18 kDa Translocator Protein TSPO Is a Mediator of Astrocyte Reactivity
Tournier, Benjamin B.
Bouteldja, Farha
Amossee, Quentin
Nicolaides, Alekos
Azevedo, Marcelo Duarte
Tenenbaum, Liliane
Garibotto, Valentina
Ceyzeriat, Kelly
Millet, Philippe
ACS OMEGA, 2023, : 31225 - 31236
[50] Adventures in Translocation: Studies of the Translocator Protein (TSPO) 18 kDa
Danon, Jonathan J.
Tregeagle, Dane F. L.
Kassiou, Michael
AUSTRALIAN JOURNAL OF CHEMISTRY, 2021, 74 (11) : 749 - 757

← 1 2 3 4 5 →