The translocator protein (TSPO): A novel target for cancer chemotherapy

被引：73

作者：

Austin, Christopher J. D. ^{[1
]}

Kahlert, Jan ^{[1
]}

Kassiou, Michael ^{[1
]}

Rendina, Louis M. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2013年 / 45卷 / 07期

关键词：

Translocator protein; TSPO; Cancer; Apoptosis; Cell homoeostasis; PERIPHERAL BENZODIAZEPINE-RECEPTOR; 18 KDA TSPO; MITOCHONDRIAL PERMEABILITY TRANSITION; DEPENDENT ANION CHANNELS; BINDING-SITES; COLONIC ADENOCARCINOMA; CHOLESTEROL TRANSPORT; DISEASE STATES; LIGANDS; TUMORS;

D O I：

10.1016/j.biocel.2013.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The translocator protein (TSPO) is an 18 kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the mitochondrial permeability transition pore (MFTP). Omnipresent in almost all tissues, TSPO up-regulation has been connected to neuronal damage and inflammation, making the protein an important bio-imaging marker for disease progression. More recently, TSPO has attracted attention as a possible molecular target for tumour imaging and chemotherapy. In this review we summarize TSPO's molecular characteristics and highlight research progress in recent years in the field of TSPO-targeted cancer diagnostics and treatments. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

引用

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页码：1212 / 1216

页数：5

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