Lack of Gender Influence on Cortical and Subcortical Gray Matter Development in Childhood-Onset Schizophrenia

被引：14

作者：

Weisinger, Brian ^{[1
]}

Greenstein, Deanna ^{[1
]}

Mattai, Anand ^{[1
]}

Clasen, Liv ^{[1
]}

Lalonde, Francois ^{[1
]}

Feldman, Sara ^{[1
]}

Miller, Rachel ^{[1
]}

Tossell, Julia W. ^{[1
]}

Vyas, Nora S. ^{[1
]}

Stidd, Reva ^{[1
]}

David, Christopher ^{[1
]}

Gogtay, Nitin ^{[1
]}

机构：

[1] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA

来源：

SCHIZOPHRENIA BULLETIN | 2013年 / 39卷 / 01期

关键词：

schizophrenia; adolescent; sex differences; cortical; subcortical; gray matter; gender; childhood-onset; FIRST-EPISODE SCHIZOPHRENIA; SEX-DIFFERENCES; BRAIN-DEVELOPMENT; GEOMETRICALLY ACCURATE; HIPPOCAMPAL VOLUMES; AMYGDALA VOLUME; MRI DATA; ADOLESCENCE; 1ST-EPISODE; MORPHOLOGY;

D O I：

10.1093/schbul/sbr049

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Progressive cortical gray matter (GM) abnormalities are an established feature of schizophrenia and are more pronounced in rare, severe, and treatment refractory childhood-onset schizophrenia (COS) cases. The effect of sex on brain development in schizophrenia is poorly understood and studies to date have produced inconsistent results. >Methods: Using the largest to date longitudinal sample of COS cases (n = 104, scans = 249, Male/Female [M/F] = 57/47), we compared COS sex differences with sex differences in a sample of matched typically developing children (n = 104, scans = 244, M/F = 57/47), to determine whether or not sex had differential effects on cortical and subcortical brain development in COS. Results: Our results showed no significant differential sex effects in COS for either GM cortical thickness or subcortical volume development (sex x diagnosis x age interaction; false discovery rate q = 0.05). Conclusion: Sex appears to play a similar role in cortical and subcortical GM development in COS as it does in normally developing children.

引用

页码：52 / 58

页数：7

共 50 条

[41] Childhood-Onset Schizophrenia: The Challenge of Diagnosis
Gochman, Peter
Miller, Rachel
Rapoport, Judith L.
CURRENT PSYCHIATRY REPORTS, 2011, 13 (05) : 321 - 322
[42] Obstetrical complications in childhood-onset schizophrenia
Nicolson, R
Giedd, J
Malaspina, D
Lenane, M
Fernandez, T
Bedwell, J
Berman, A
Susser, E
Rapoport, JL
SCHIZOPHRENIA RESEARCH, 1999, 36 (1-3) : 93 - 93
[43] Childhood-Onset Schizophrenia: The Challenge of Diagnosis
Peter Gochman
Rachel Miller
Judith L. Rapoport
Current Psychiatry Reports, 2011, 13 : 321 - 322
[44] Childhood-onset schizophrenia: Research update
Kumra, S
Shaw, M
Merka, P
Nakayama, E
Augustin, R
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2001, 46 (10): : 923 - 930
[45] PREMORBID IMPAIRMENTS IN CHILDHOOD-ONSET SCHIZOPHRENIA
Driver, David I.
Greenstein, Deanna
Farmer, Madison
Rapoport, Judith
Gogtay, Nitin
SCHIZOPHRENIA RESEARCH, 2014, 153 : S312 - S312
[46] Antipsychotic medication for childhood-onset schizophrenia
Kennedy, Eilis
Kumar, Ajit
Datta, Soumitra S.
SCHIZOPHRENIA BULLETIN, 2007, 33 (05) : 1082 - 1083
[47] Lessons from childhood-onset schizophrenia
Nicolson, R
Lenane, M
Hamburger, SD
Fernandez, T
Bedwell, J
Rapoport, JL
BRAIN RESEARCH REVIEWS, 2000, 31 (2-3) : 147 - 156
[48] Update on childhood-onset schizophrenia.
Rapoport J.L.
Inoff-Germain G.
Current Psychiatry Reports, 2000, 2 (5) : 410 - 415
[49] Antipsychotic medication for childhood-onset schizophrenia
Kennedy, E.
Kumar, A.
Datta, S. S.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2007, (03):
[50] THE CLINICAL PRESENTATION OF CHILDHOOD-ONSET SCHIZOPHRENIA
RUSSELL, AT
SCHIZOPHRENIA BULLETIN, 1994, 20 (04) : 631 - 646

← 1 2 3 4 5 →