Lack of Gender Influence on Cortical and Subcortical Gray Matter Development in Childhood-Onset Schizophrenia

被引：14

作者：

Weisinger, Brian ^{[1
]}

Greenstein, Deanna ^{[1
]}

Mattai, Anand ^{[1
]}

Clasen, Liv ^{[1
]}

Lalonde, Francois ^{[1
]}

Feldman, Sara ^{[1
]}

Miller, Rachel ^{[1
]}

Tossell, Julia W. ^{[1
]}

Vyas, Nora S. ^{[1
]}

Stidd, Reva ^{[1
]}

David, Christopher ^{[1
]}

Gogtay, Nitin ^{[1
]}

机构：

[1] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA

来源：

SCHIZOPHRENIA BULLETIN | 2013年 / 39卷 / 01期

关键词：

schizophrenia; adolescent; sex differences; cortical; subcortical; gray matter; gender; childhood-onset; FIRST-EPISODE SCHIZOPHRENIA; SEX-DIFFERENCES; BRAIN-DEVELOPMENT; GEOMETRICALLY ACCURATE; HIPPOCAMPAL VOLUMES; AMYGDALA VOLUME; MRI DATA; ADOLESCENCE; 1ST-EPISODE; MORPHOLOGY;

D O I：

10.1093/schbul/sbr049

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Progressive cortical gray matter (GM) abnormalities are an established feature of schizophrenia and are more pronounced in rare, severe, and treatment refractory childhood-onset schizophrenia (COS) cases. The effect of sex on brain development in schizophrenia is poorly understood and studies to date have produced inconsistent results. >Methods: Using the largest to date longitudinal sample of COS cases (n = 104, scans = 249, Male/Female [M/F] = 57/47), we compared COS sex differences with sex differences in a sample of matched typically developing children (n = 104, scans = 244, M/F = 57/47), to determine whether or not sex had differential effects on cortical and subcortical brain development in COS. Results: Our results showed no significant differential sex effects in COS for either GM cortical thickness or subcortical volume development (sex x diagnosis x age interaction; false discovery rate q = 0.05). Conclusion: Sex appears to play a similar role in cortical and subcortical GM development in COS as it does in normally developing children.

引用

页码：52 / 58

页数：7

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