Thickness Mapping of the Cornea and Epithelium Using Optical Coherence Tomography

被引:75
|
作者
Haque, Sameena [1 ]
Jones, Lyndon [1 ]
Simpson, Trefford [1 ]
机构
[1] Univ Waterloo, Sch Optometry, Ctr Contact Lens Res, Waterloo, ON N2L 3G1, Canada
关键词
corneal thickness; epithelial thickness; optical coherence tomography; peripheral thickness; keratoconus;
D O I
10.1097/OPX.0b013e318188892c
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose. To measure corneal and epithelial thickness across four meridians using Optical Coherence Tomography (OCT) and to compare these measurements between normal non-lens wearers (NLW), rigid gas permeable (RGP) lens wearers, and RCP-wearing keratoconics (KC). Methods. Both eyes of 60 Subjects were measured (20 NLW, nine female:11 male, 27.6 +/- 5.9 years; 20 RGP, 20 female, 23.9 +/- 7.6 years; and 20 KC, seven female:13 male, 32.4 +/- 8.1 years). A customized fixation target employing LEDs in eight directions of gaze was attached to the OCT and corneal images obtained. Raw OCT scans were analyzed to yield values for cornea) and epithelial thickness and color-coded maps were compiled. Results. Central corneal thickness (CCT) was thinnest in KC (447 +/- 68 mu m) and similar between RGP (518 +/- 32 mu m; P-KC < 0.001) and NLW (517 +/- 21 mu m) (P-KC < 0.001 NLW > 0.05). Peripheral corneal thickness in NLW was thickest in the superior temporal and thinnest in the interior (1) regions (superior temporal(thickest) vs. l(thinnest) p < 0.001). Central epithelial thickness was thinnest in KC (44 +/- 7 mu m), followed by RGP (50 +/- 4 mu m), then NLW (54 +/- 2 mu m) (P-KC < 0.001 NLW p(RGP) < 0.05). Central epithelial thickness in the KC group was significantly thinner than in the RGP group (p < 0.001). In the NLW group, peripheral epithelial thickness was thicker (63 +/- 5 mu m) than central (p < 0.001) and was thickest in the superior (S) region and thinnest in the interior (1) region (S-thickest vs. I-thinnest p < 0.001). KC epithelium was thinnest in the interior temporal meridian (42 +/- 5 mu m). Conclusions. Thickness of the normal cornea and epithelium was greatest in (lie Superior region. In all groups, the inferior cornea and epithelium was thinnest, and to a greater extent in the KC group. (Optom Vis Sci 2008;85:963-976)
引用
收藏
页码:963 / 976
页数:14
相关论文
共 50 条
  • [41] Evaluation of choroidal thickness in psoriasis using optical coherence tomography
    Salih Uzun
    Emre Pehlivan
    International Ophthalmology, 2017, 37 : 313 - 314
  • [42] Airway wall thickness assessed using computed tomography and optical coherence tomography
    Coxson, Harvey O.
    Quiney, Brendan
    Sin, Don D.
    Xing, Li
    McWilliams, Annette M.
    Mayo, John R.
    Lam, Stephen
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (11) : 1201 - 1206
  • [43] Deformation velocity imaging using optical coherence tomography and its applications to the cornea
    Lawman, Samuel
    Madden, Peter W.
    Romano, Vito
    Dong, Yue
    Mason, Sharon
    Williams, Bryan M.
    Kaye, Stephen B.
    Willoughby, Colin E.
    Harding, Simon P.
    Shen, Yao-Chun
    Zheng, Yalin
    BIOMEDICAL OPTICS EXPRESS, 2017, 8 (12): : 5579 - 5593
  • [44] Optical coherence tomography of cornea and anterior segment of the eye
    Koop, N
    Brinkmann, R
    Lankenau, E
    Flache, S
    Engelhardt, R
    Birngruber, R
    OPHTHALMOLOGE, 1997, 94 (07): : 481 - 486
  • [45] Comparison of human central cornea and limbus in vivo using optical coherence tomography
    Feng, YW
    Simpson, TL
    OPTOMETRY AND VISION SCIENCE, 2005, 82 (05) : 416 - 419
  • [46] Cornea characterization using a combined multiphoton microscopy and optical coherence tomography system
    Lai, Tom
    Tang, Shuo
    BIOMEDICAL OPTICS EXPRESS, 2014, 5 (05): : 1494 - 1511
  • [47] Nondestructive quantification of analyte diffusion in cornea and sclera using optical coherence tomography
    Ghosn, Mohamad G.
    Tuchin, Valery V.
    Larin, Kirill V.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2007, 48 (06) : 2726 - 2733
  • [48] Accuracy of cornea and lens biometry using anterior segment optical coherence tomography
    Dunne, Mark C. M.
    Davies, Leon N.
    Wolffsohn, James S.
    JOURNAL OF BIOMEDICAL OPTICS, 2007, 12 (06)
  • [49] Retinal thickness measurements with optical coherence biometry and optical coherence tomography
    Resch, Miklos D.
    Takats, Judit
    Csakany, Bela
    Maneschg, Otto
    Marsovszky, Laszlo
    Szabo, Antal
    Papp, Andras
    Nemeth, Janos
    SPEKTRUM DER AUGENHEILKUNDE, 2014, 28 (03) : 121 - 125
  • [50] Quantifying the effect of milli-molar glucose concentration on thickness of rabbit cornea with Optical Coherence Tomography
    Ghosn, Mohamad G.
    Leba, Michael
    Vijayananda, Astha
    Ansari, Rafat R.
    Larin, Kirill V.
    OPTICAL DIAGNOSTICS AND SENSING IX, 2009, 7186