Topical Treatment of Tinea Pedis Using 6% Coriander Oil in Unguentum Leniens: A Randomized, Controlled, Comparative Pilot Study

被引：6
|
作者：
Beikert, F. C. [1 ]
Anastasiadou, Z. [1 ]
Fritzen, B. [2 ]
Frank, U. [3 ]
Augustin, M. [1 ]
机构：
[1] Univ Med Ctr Hamburg, Inst Hlth Serv Res Dermatol & Nursing, DE-20246 Hamburg, Germany
[2] HELIOS Hosp Krefeld, Dept Dermatol Venerol & Allergol, Krefeld, Germany
[3] Univ Med Ctr Heidelberg, Dept Hosp Hyg & Environm Hlth, Heidelberg, Germany
来源：
DERMATOLOGY | 2013年 / 226卷 / 01期
关键词：
Coriander oil; Tinea pedis; Fungal foot infection; Trichophyton rubrum; Trichophyton mentagrophytes; Coriandrum sativum L; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIFUNGAL ACTIVITY; SATIVUM L; PREVALENCE; ALLERGY;
D O I：
10.1159/000346641
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: The antifungal activity of coriander oil has already been demonstrated in vitro. Objective: Evaluation of the efficacy and tolerability of 6% coriander oil in unguentum leniens in the treatment of interdigital tinea pedis. Methods: Half-side comparative pilot study on subjects with symmetric, bilateral interdigital tinea pedis. Active drug and placebo control were applied twice daily on the affected areas, and follow-up visits were performed on days 14 and 28. Results: 40 participants (mean age 52.5 years, 60% male) were included in the study. For 6% coriander oil in unguentum leniens, a highly significant improvement of the clinical signs (p < 0.0001) was observed during the entire observation period; the number of positive fungal cultures also tended to decrease (p = 0.0654). The tolerability of the tested substances was good. Conclusion: Coriander oil is effective and well tolerated in the treatment of interdigital tinea pedis. Copyright (C) 2013 S. Karger AG, Basel
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页码：47 / 51
页数：5
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