Topical Treatment of Tinea Pedis Using 6% Coriander Oil in Unguentum Leniens: A Randomized, Controlled, Comparative Pilot Study

被引:6
|
作者
Beikert, F. C. [1 ]
Anastasiadou, Z. [1 ]
Fritzen, B. [2 ]
Frank, U. [3 ]
Augustin, M. [1 ]
机构
[1] Univ Med Ctr Hamburg, Inst Hlth Serv Res Dermatol & Nursing, DE-20246 Hamburg, Germany
[2] HELIOS Hosp Krefeld, Dept Dermatol Venerol & Allergol, Krefeld, Germany
[3] Univ Med Ctr Heidelberg, Dept Hosp Hyg & Environm Hlth, Heidelberg, Germany
关键词
Coriander oil; Tinea pedis; Fungal foot infection; Trichophyton rubrum; Trichophyton mentagrophytes; Coriandrum sativum L; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIFUNGAL ACTIVITY; SATIVUM L; PREVALENCE; ALLERGY;
D O I
10.1159/000346641
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: The antifungal activity of coriander oil has already been demonstrated in vitro. Objective: Evaluation of the efficacy and tolerability of 6% coriander oil in unguentum leniens in the treatment of interdigital tinea pedis. Methods: Half-side comparative pilot study on subjects with symmetric, bilateral interdigital tinea pedis. Active drug and placebo control were applied twice daily on the affected areas, and follow-up visits were performed on days 14 and 28. Results: 40 participants (mean age 52.5 years, 60% male) were included in the study. For 6% coriander oil in unguentum leniens, a highly significant improvement of the clinical signs (p < 0.0001) was observed during the entire observation period; the number of positive fungal cultures also tended to decrease (p = 0.0654). The tolerability of the tested substances was good. Conclusion: Coriander oil is effective and well tolerated in the treatment of interdigital tinea pedis. Copyright (C) 2013 S. Karger AG, Basel
引用
收藏
页码:47 / 51
页数:5
相关论文
共 50 条
  • [21] Treatment of interdigital-type tinea pedis with a 2-week regimen of wearing hygienic socks loaded with antifungal microcapsules: A randomized, double-blind, placebo-controlled study
    Yuen, Chun-Wah Marcus
    Yip, Joanne
    Cheung, Hing-Cheong
    Liu, Li-Wei
    Luk, Chi-Him
    Wai, W-Celeste
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2013, 69 (03) : 495 - 496
  • [22] Effect of the supplementation of virgin coriander seed oil on reducing reactivity in healthy women with sensitive skin: a randomized double-blind placebo-controlled pilot clinical study
    Kern, Catherine
    Gombert, Christian
    Roso, Alicia
    Garcia, Christine
    FOOD & NUTRITION RESEARCH, 2022, 66
  • [23] Treatment of patients with severe sepsis using Ulinastatin and Thymosin α1: a prospective, randomized, controlled pilot study
    Chen Hao
    He Ming-yan
    Li Yu-min
    CHINESE MEDICAL JOURNAL, 2009, 122 (08) : 883 - 888
  • [24] Nonablative 1550-nm fractional laser therapy versus triple topical therapy for the treatment of melasma: A randomized controlled pilot study
    Kroon, Marije W.
    Wind, Bas S.
    Beek, Johan F.
    van der Veen, J. P. Wietze
    Nieuweboer-Krobotova, Ludmila
    Bos, Jan D.
    Wolkerstorfer, Albert
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2011, 64 (03) : 516 - 523
  • [25] A Comparative Study of the Safety and Efficacy of 75% Mulberry (Morus alba) Extract Oil Versus Placebo as a Topical Treatment for Melasma: A Randomized, Single-Blind, Placebo-Controlled Trial
    Alvin, Glen
    Catambay, Nino
    Vergara, Ailynne
    Jasmin Jamora, Maria
    JOURNAL OF DRUGS IN DERMATOLOGY, 2011, 10 (09) : 1025 - 1031
  • [26] Treatment of Eyebrow Hypotrichosis Using Bimatoprost: A Randomized, Double-Blind, Vehicle-Controlled Pilot Study
    Beer, Kenneth R.
    Julius, Hillary
    Dunn, Monica
    Wilson, Fred
    DERMATOLOGIC SURGERY, 2013, 39 (07) : 1079 - 1087
  • [27] Efficacy of a mixture of neem seed oil (Azadirachta indica) and coconut oil (Cocos nucifera) for topical treatment of tungiasis. A randomized controlled, proof-of-principle study
    Elson, Lynne
    Randu, Kithi
    Feldmeier, Hermann
    Fillinger, Ulrike
    PLOS NEGLECTED TROPICAL DISEASES, 2019, 13 (11):
  • [28] Topical Cyperus rotundus essential oil for treatment of axillary hyperpigmentation: a randomized, double-blind, active- and placebo-controlled study
    Mohammed, G. F.
    CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2022, 47 (03) : 534 - 541
  • [29] Topical Omega-3 Polyunsaturated Fatty Acids for the Treatment of Dry Eye - Results from a Pilot Randomized Controlled Masked-Observer Study
    Kaercher, Thomas
    Messmer, Elisabeth M.
    Berninger, Thomas
    Huber-van der Velden, Klaudia K.
    Geiger, Raphaela
    Cipriano-Bonvin, Pauline
    Jacobi, Christina
    CLINICAL OPHTHALMOLOGY, 2022, 16 : 4021 - 4031
  • [30] A Comparative Study on Short-Term Effects of Compression Orthosis and Exercises in the Treatment of Pectus Carinatum: A Randomized Controlled Pilot Feasibility Trial
    Giray, Esra
    Ermerak, Nezih Onur
    Bahar-Ozdemir, Yeliz
    Kalkandelen, Melihat
    Yuksel, Mustafa
    Gunduz, Osman Hakan
    Akyuz, Gulseren
    EUROPEAN JOURNAL OF PEDIATRIC SURGERY, 2021, 31 (02) : 147 - 156