Long-term B-Lymphocyte Depletion With Rituximab in Patients With Relapsing-Remitting Multiple Sclerosis

被引：35
|
作者：
Stuve, Olaf [2 ,3 ]
Leussink, Verena I. [1 ]
Froehlich, Ruth [1 ]
Hemmer, Bernhard [4 ]
Hartung, Hans-Peter [1 ]
Menge, Til [1 ]
Kieseier, Bernd C. [1 ]
机构：
[1] Univ Dusseldorf, Dept Neurol, D-40225 Dusseldorf, Germany
[2] Univ Texas SW Med Ctr Dallas, Div Neurol, Med Serv, Dallas Vet Affairs Med Ctr, Dallas, TX 75390 USA
[3] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75390 USA
[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-8000 Munich, Germany
来源：
ARCHIVES OF NEUROLOGY | 2009年 / 66卷 / 02期
关键词：
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; CEREBROSPINAL-FLUID; CELL;
D O I：
10.1001/archneurol.2008.551
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To describe 2 patients with relapsing-remitting multiple sclerosis (RRMS) receiving longterm treatment with the monoclonal antibody rituximab. The clinical and paraclinical efficacy of rituximab was demonstrated recently in a phase 2 clinical trial in patients with RRMS. Design: Case series. Setting: Tertiary care university medical center. Patients: Two young patients with highly active RRMS in whom standard therapy had failed before receiving rituximab for up to 48 months. Main Outcome Measures: Relapse rate, clinical disability, and results of magnetic resonance imaging. Results: Both patients tolerated rituximab treatment well and have been clinically stable throughout the study period. Conclusion: Long-term therapy with rituximab appears safe and effective in some patients with RRMS. Our observation should be confirmed in controlled long-term trials.
引用
收藏
页码：259 / 261
页数：3
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