user

Long-term B-Lymphocyte Depletion With Rituximab in Patients With Relapsing-Remitting Multiple Sclerosis

被引：35
|
作者：
Stuve, Olaf [2 ,3 ]
Leussink, Verena I. [1 ]
Froehlich, Ruth [1 ]
Hemmer, Bernhard [4 ]
Hartung, Hans-Peter [1 ]
Menge, Til [1 ]
Kieseier, Bernd C. [1 ]
机构：
[1] Univ Dusseldorf, Dept Neurol, D-40225 Dusseldorf, Germany
[2] Univ Texas SW Med Ctr Dallas, Div Neurol, Med Serv, Dallas Vet Affairs Med Ctr, Dallas, TX 75390 USA
[3] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75390 USA
[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-8000 Munich, Germany
来源：
ARCHIVES OF NEUROLOGY | 2009年 / 66卷 / 02期
关键词：
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; CEREBROSPINAL-FLUID; CELL;
D O I：
10.1001/archneurol.2008.551
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To describe 2 patients with relapsing-remitting multiple sclerosis (RRMS) receiving longterm treatment with the monoclonal antibody rituximab. The clinical and paraclinical efficacy of rituximab was demonstrated recently in a phase 2 clinical trial in patients with RRMS. Design: Case series. Setting: Tertiary care university medical center. Patients: Two young patients with highly active RRMS in whom standard therapy had failed before receiving rituximab for up to 48 months. Main Outcome Measures: Relapse rate, clinical disability, and results of magnetic resonance imaging. Results: Both patients tolerated rituximab treatment well and have been clinically stable throughout the study period. Conclusion: Long-term therapy with rituximab appears safe and effective in some patients with RRMS. Our observation should be confirmed in controlled long-term trials.
引用
收藏
页码：259 / 261
页数：3
相关论文
共 50 条
  • [31] Long-term MRI observations of childhood-onset relapsing-remitting multiple sclerosis
    Balássy, C
    Bernert, G
    Wöber-Bingöl, C
    Csapó, B
    Kornek, B
    Széles, J
    Fleischmann, D
    Prayer, D
    [J]. NEUROPEDIATRICS, 2001, 32 (01) : 28 - 37
  • [32] Long-term effect of fingolimod on cardiovascular functioning in people with relapsing-remitting multiple sclerosis
    Haase, R.
    Forberger, C.
    Schilling, M.
    Piatkowski, F.
    Akgun, K.
    Rudiger, H.
    Ziemssen, T.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2021, 27 (2_SUPPL) : 609 - 610
  • [33] Discontinuation and dose reduction of rituximab in relapsing-remitting multiple sclerosis
    Boremalm, Malin
    Sundstrom, Peter
    Salzer, Jonatan
    [J]. JOURNAL OF NEUROLOGY, 2021, 268 (06) : 2161 - 2168
  • [34] Long-term effect of natalizumab in a French cohort of patients with relapsing-remitting multiple sclerosis: TYSTEN cohort
    Bigaut, Kevin
    Fabacher, Thibaut
    Collongues, Nicolas
    Kremer, Laurent
    Fleury, Marie-Celine
    Ongagna, Jean-Claude
    De Seze, Jerome
    [J]. NEUROLOGY, 2018, 90
  • [35] Clinical and demographic predictors of long-term disability in patients with relapsing-remitting multiple sclerosis - A systematic review
    Langer-Gould, Annette
    Popat, Rita A.
    Huang, Stella M.
    Cobb, Kristin
    Fontoura, Paulo
    Gould, Michael K.
    Nelson, Lorene M.
    [J]. ARCHIVES OF NEUROLOGY, 2006, 63 (12) : 1686 - 1691
  • [36] Long-Term Stability of Neuroaxonal Structure in Alemtuzumab-Treated Relapsing-Remitting Multiple Sclerosis Patients
    Chan, Jillian K.
    de Lapiscina, Elena Hernandez Martinez
    Taylor, Carolyn
    Nguyen, Ai-Lan
    Alba-Arbalat, Salut
    Devonshire, Virginia
    Sayao, Ana-Luiza
    Carruthers, Robert
    Costello, Fiona
    Traboulsee, Anthony
    [J]. JOURNAL OF NEURO-OPHTHALMOLOGY, 2020, 40 (01) : 37 - 43
  • [37] Relapsing-remitting multiple sclerosis
    Flores, A
    Ochoa, E
    Zamora, S
    Barrientos, UN
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2003, 214 (1-2) : 110 - 110
  • [38] Long-term follow-up of immunomodulatory therapies in early relapsing-remitting multiple sclerosis
    Haas, Judith
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2008, 14 : S45 - S46
  • [39] The impact of long-term treatment with disease modifying therapy on disability progression in relapsing-remitting multiple sclerosis patients
    Carra, Adriana J.
    Onaha, Patricia S.
    Sinay, Vladimiro
    Halfon, Mario J.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2008, 14 : S36 - S36
  • [40] Improved quality of life among relapsing-remitting multiple sclerosis patients treated long-term with glatiramer acetate
    Oleen-Burkey, M.
    Johnson, K. P.
    [J]. VALUE IN HEALTH, 2008, 11 (03) : A147 - A147
12345