Effect of hyperthermia on the action of methotrexate against the growth of Ehrlich ascites carcinoma cells

被引：0
|
作者：
AlShabanah, OA [1 ]
Osman, AMM [1 ]
AlHarbi, MM [1 ]
AlGharably, NM [1 ]
Bekairi, AM [1 ]
ElMerzabani, MM [1 ]
机构：
[1] CAIRO UNIV,INST CANC,PHARMACOL UNIT,CAIRO,EGYPT
来源：
MEDICAL SCIENCE RESEARCH | 1996年 / 24卷 / 04期
关键词：
hyperthermia; methotrexate; Ehrlich cell; cytotoxicity-interaction;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hyperthermia (HPT) at 43 degrees C for 30 min increased the cytotoxicity activity of the antimetabolite methotrexate (MXT) against the growth of Ehrlich ascites carcinoma cells. There was significant delay in tumour growth with 92% inhibition of tumour volume. There were 74, 29.5 and 36% decreases respectively in the rate of DNA, RNA and protein synthesis of tumour cells after treatment with combination of MTX and HPT. Moreover, combination therapy produced pronounced inhibitory effects on cholesterol, total lipid and acid phosphatase activity. Our results suggest the benefit of using HPT to sensitise tumour cells to the cytotoxic activity of MTX. At the same time, it may sensitise normal tissue to the action of antimetabolite drugs.
引用
收藏
页码：275 / 277
页数：3
相关论文
共 50 条
  • [1] EFFECT OF HYPERTHERMIA ON GROWTH OF EHRLICH ASCITES TUMOR-CELLS
    FUNG, KP
    LAM, WP
    WEN, HL
    CHOY, YM
    LEE, CY
    [J]. CANCER BIOCHEMISTRY BIOPHYSICS, 1988, 10 (02): : 117 - 124
  • [2] ON EFFECT OF REPEATED HYPERTHERMIA ON EHRLICH-ASCITES MICE CARCINOMA
    VONARDEN.M
    REITNAUER, PG
    [J]. ARCHIV FUR GESCHWULSTFORSCHUNG, 1970, 35 (04): : 369 - +
  • [3] Effect of Dopamine on Ehrlich Ascites Carcinoma Cells
    D. A. Moshkov
    S. P. Romanchenko
    E. Yu. Parnyshkova
    E. N. Bezgina
    S. I. Zaichkina
    L. L. Pavlik
    [J]. Bulletin of Experimental Biology and Medicine, 2013, 154 : 686 - 691
  • [4] EFFECT OF ULTRASOUND ON CELLS OF EHRLICH ASCITES CARCINOMA
    MITYUSHI.VM
    ELPINER, IY
    [J]. BIOPHYSICS-USSR, 1969, 14 (03): : 531 - &
  • [5] Effect of Dopamine on Ehrlich Ascites Carcinoma Cells
    Moshkov, D. A.
    Romanchenko, S. P.
    Parnyshkova, E. Yu.
    Bezgina, E. N.
    Zaichkina, S. I.
    Pavlik, L. L.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 154 (05) : 686 - 691
  • [6] SYNTHESIS AND RETENTION OF METHOTREXATE POLYGLUTAMATES IN EHRLICH ASCITES-CARCINOMA CELLS
    BALINSKA, M
    [J]. DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, 1986, 12 (6-7) : 551 - 554
  • [7] ACTION OF DEOXYRIBONUCLEASE AND RIBONUCLEASE ON GROWTH OF EHRLICH ASCITES CARCINOMA IN MICE
    DELAMIRANDE, G
    [J]. NATURE, 1961, 192 (479) : 52 - &
  • [8] ACTION OF SUGARS ON METHIONINE TRANSFER IN EHRLICH ASCITES CARCINOMA CELLS
    HIRSCHFELD, I
    FAGARASAN, M
    [J]. EXPERIENTIA, 1969, 25 (04): : 363 - +
  • [9] ACTION OF PHOSPHOLIPIDS ON THE CYTOTOXIC EFFECT OF RABBIT ANTIBODIES AGAINST EHRLICH ASCITES TUMOUR CELLS
    GINSBURG, I
    [J]. BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY, 1960, 41 (06): : 648 - 659
  • [10] INHIBITION OF SUGAR UPTAKE BY METHOTREXATE IN CULTURED EHRLICH ASCITES-CARCINOMA CELLS
    KAMINSKAS, E
    [J]. CANCER RESEARCH, 1979, 39 (01) : 90 - 95
12345