Effect of hyperthermia on the action of methotrexate against the growth of Ehrlich ascites carcinoma cells

被引：0
|
作者：
AlShabanah, OA [1 ]
Osman, AMM [1 ]
AlHarbi, MM [1 ]
AlGharably, NM [1 ]
Bekairi, AM [1 ]
ElMerzabani, MM [1 ]
机构：
[1] CAIRO UNIV,INST CANC,PHARMACOL UNIT,CAIRO,EGYPT
来源：
MEDICAL SCIENCE RESEARCH | 1996年 / 24卷 / 04期
关键词：
hyperthermia; methotrexate; Ehrlich cell; cytotoxicity-interaction;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hyperthermia (HPT) at 43 degrees C for 30 min increased the cytotoxicity activity of the antimetabolite methotrexate (MXT) against the growth of Ehrlich ascites carcinoma cells. There was significant delay in tumour growth with 92% inhibition of tumour volume. There were 74, 29.5 and 36% decreases respectively in the rate of DNA, RNA and protein synthesis of tumour cells after treatment with combination of MTX and HPT. Moreover, combination therapy produced pronounced inhibitory effects on cholesterol, total lipid and acid phosphatase activity. Our results suggest the benefit of using HPT to sensitise tumour cells to the cytotoxic activity of MTX. At the same time, it may sensitise normal tissue to the action of antimetabolite drugs.
引用
收藏
页码：275 / 277
页数：3
相关论文
共 50 条
  • [41] CONTROL BY HYPERTHERMIA OF ORNITHINE DECARBOXYLASE IN EHRLICH ASCITES TUMOR-CELLS
    MATSUIYUASA, I
    OTANI, S
    MORISAWA, S
    KAGEYAMA, K
    ONOYAMA, Y
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1014 (03) : 225 - 228
  • [42] Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells
    Déborah R. P. Meireles
    Heloísa M. B. Fernandes
    Thaísa L. Rolim
    Tatianne M. Batista
    Vivianne M. Mangueira
    Tatyanna K. G. de Sousa
    João C. L. R. Pita
    Aline L. Xavier
    Daiene M. Beltrão
    Josean F. Tavares
    Marcelo S. Silva
    Karina K. P. Medeiros
    Marianna V. Sobral
    [J]. Revista Brasileira de Farmacognosia, 2016, 26 : 751 - 758
  • [43] Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells
    Meireles, Deborah R. P.
    Fernandes, Heloisa M. B.
    Rolim, Thaisa L.
    Batista, Tatianne M.
    Mangueira, Vivianne M.
    de Sousa, Tatyanna K. G.
    Pita, Joao C. L. R.
    Xavier, Aline L.
    Beltrao, Daiene M.
    Tavares, Josean F.
    Silva, Marcelo S.
    Medeiros, Karina K. P.
    Sobral, Marianna V.
    [J]. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2016, 26 (06): : 751 - 758
  • [44] Xanthones and Antitumor Activity of Bombax ceiba Against Ehrlich Ascites Carcinoma Cells in Mice
    El-Toumy, Sayed A.
    Hawas, Usama W.
    Taie, Hanan A. A.
    [J]. CHEMISTRY OF NATURAL COMPOUNDS, 2013, 49 (05) : 945 - 950
  • [45] Xanthones and Antitumor Activity of Bombax ceiba Against Ehrlich Ascites Carcinoma Cells in Mice
    Sayed A. El-Toumy
    Usama W. Hawas
    Hanan A. A. Taie
    [J]. Chemistry of Natural Compounds, 2013, 49 : 945 - 950
  • [46] ACTION OF ANTIBODIES AND PLASMIN ON EHRLICH ASCITES TUMOUR CELLS
    GINSBURG, I
    RAM, M
    [J]. NATURE, 1960, 185 (4709) : 328 - 330
  • [47] EFFECT OF METHYL METHANE SULFONATE ON EHRLICH ASCITES CARCINOMA CELLS: DOSE EFFECT RELATIONSHIPS
    Mahadimane, P. Vishwaprakash
    Vasudev, V.
    [J]. INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2013, 3 (02): : L22 - L31
  • [48] INFLUENCE OF DETERGENTS ON GROWTH OF EHRLICH-ASCITES CARCINOMA
    HANSON, H
    BOHLEY, P
    [J]. ZEITSCHRIFT FUR KREBSFORSCHUNG, 1968, 71 (01): : 51 - &
  • [49] EFFECT OF MONOVALENT CATIONS ON CHROMATIN STRUCTURE IN EHRLICH ASCITES-CARCINOMA CELLS
    DANKO, IM
    KAZMIN, SD
    [J]. BIOCHEMISTRY-MOSCOW, 1993, 58 (03) : 237 - 242
  • [50] EFFECT OF X-IRRADIATION ON DNA SYNTHESIS IN EHRLICH ASCITES CARCINOMA CELLS
    SUNG, SC
    [J]. CANADIAN JOURNAL OF BIOCHEMISTRY, 1965, 43 (07): : 859 - &
12345