Effect of Dopamine on Ehrlich Ascites Carcinoma Cells

Morphological studies showed that daily intraperitoneal injections of dopamine in doses of 10–2 and 10–1 M down-regulates the general number of cells in the Ehrlich ascites carcinoma in 10 and 30 times and decreases their diameter by 27% and 59%, respectively (as compared to the control animals received physiological saline). According to ultrastructural data these injections were followed by the abnormal changes in microvilluses, forming the specifi c moiré fringes in cytosol, thickening of cortical layer, and a signifi cant increase in fi lament reticulum density (actin fi bers) in tumor cells of treatment group specimens. We concluded that the oncocytotoxic effect of dopamine was related to the induced polymerization of cytosol actin.