Methylenecyclopropane analogues of nucleosides:: Synthesis, absolute configuration, and enantioselectivity of antiviral effect of (R)-(-)- and (S)-(+)-synadenol

被引：3

作者：

Qiu, YL

Hempel, A

Camerman, N

Camerman, A

Geiser, F

Ptak, RG

Breitenbach, JM

Kira, T

Li, L

Gullen, E

Cheng, YC

Drach, JC

Zemlicka, J ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Detroit, MI 48201 USA

[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

[3] Ardono Res, Seattle, WA 98105 USA

[4] Chiral Technol Inc, Exton, PA 19341 USA

[5] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA

[6] Univ Michigan, Sch Dent, Dept Biol & Mat Sci, Ann Arbor, MI 48019 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis, absolute configuration and antiviral activity of enantiomeric antiviral agents (R)-(-)- and (S)-(+)-synadenol (2 and 3a) are described.

引用

页码：597 / 598

页数：2

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